RalA:GTP binds Myo1c:Calm1 and F-actin

Stable Identifier
R-MMU-2316348
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytoplasmic vesicle membrane, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RalA:GTP binds Myo1c:Calm1 and F-actin

Insulin causes phosphorylation and inactivation of the Ral GTPase activating complex RGC, causing RalA:GTP to accumulate and associate with the unconventional myosin Myo1c (Chen et al. 2007, Chen et al. 2011). Myo1c motors across cortical actin and interacts with the exocyst complex to tether vesicles at the plasma membrane (Chen et al. 2007).

Literature References
PubMed ID Title Journal Year
17765682 Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c

Chen, XW, Leto, D, Chiang, SH, Wang, Q, Saltiel, AR

Dev Cell 2007
21148297 A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Chen, XW, Leto, D, Xiong, T, Yu, G, Cheng, A, Decker, S, Saltiel, AR

Mol Biol Cell 2011
Participants
Input
Output
Orthologous Events
RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)
Authored
May, B  (2012-05-27)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-06-08)
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