RalA releases GDP and binds GTP (inferred from the simian RalA in Frech et al. 1990). The reaction is enhanced by guanine nucleotide exchange factors (GEFs) and opposed by GTPase-activating proteins (GAPs) which activate the intrinsic GTPase activity of RalA (Chen et al. 2011).
Frech, M, Schlichting, I, Wittinghofer, A, Chardin, P
Chen, XW, Leto, D, Xiong, T, Yu, G, Cheng, A, Decker, S, Saltiel, AR
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