15k-PGE2/F2a is reduced to dhk-PGE2/F2a by Ptgr2

Stable Identifier
R-MMU-2161638
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
15k-PGE2/F2a is reduced to dhk-PGE2/F2a by Ptgr2

In mice, prostaglandin reductase 2 (Ptgr2) is a 13-prostaglandin reductase which metabolises eicosanoids by catalysing NADH/NADPH-dependant double bond reduction in 15-keto-prostaglandin E2 (15k-PGE2) and F2alpha (15k-PGF2a) to produce 13,14-dihydro-15-keto-prostaglandin E2 (dhk-PGE2) and F2alpha (dhk-PGF2a) respectively (Chou et al. 2007).

Literature References
PubMed ID Title Journal Year
17449869 Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation

Chou, WL, Chuang, LM, Chou, CC, Wang, AH, Lawson, JA, FitzGerald, GA, Chang, ZF

J Biol Chem 2007
Participants
Catalyst Activity

13-prostaglandin reductase activity of Ptgr2 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!