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Mdk [extracellular region]
Stable Identifier
R-MMU-2160953
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
MDK, P12025
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
ALK autophosphorylation (Mus musculus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
ligand-bound ALK dimer [plasma membrane] (Mus musculus)
MDK:ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
ligand-bound ALK dimer [plasma membrane] (Mus musculus)
MDK:ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK binds JAK3 (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:JAK3 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK binds PLCG1 (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:PLCG1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK binds SHC1 (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:SHC1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK dimer binds IRS1 (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:IRS1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK phosphorylates IRS1 (Mus musculus)
Active ALK:IRS1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:pY-IRS1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK phosphorylates JAK3 (Mus musculus)
Active ALK:JAK3 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK phosphorylates PLCG1 (Mus musculus)
Active ALK:PLCG1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK phosphorylates SHC1 (Mus musculus)
Active ALK:SHC1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:p-3Y SHC1 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK recruits PI3K (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:PI3K [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Mus musculus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
ligand-bound ALK dimer [plasma membrane] (Mus musculus)
MDK:ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
ligand-bound ALK dimer [plasma membrane] (Mus musculus)
MDK:ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
MDK and PTN in ALK signaling (Mus musculus)
(PTN,MDK):PTPRZ oligomerizes (Mus musculus)
(PTN,MDK):PTPRZ [plasma membrane] (Mus musculus)
PTN,MDK [extracellular region] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Mus musculus)
(PTN,MDK):PTPRZ [plasma membrane] (Mus musculus)
PTN,MDK [extracellular region] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
ALK binds ligand midkine (MDK) (Mus musculus)
MDK:ALK [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
PTN and MDK bind to PTPRZ (Mus musculus)
(PTN,MDK):PTPRZ [plasma membrane] (Mus musculus)
PTN,MDK [extracellular region] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
PTN,MDK [extracellular region] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)
(PTN,MDK):ALK dimer [plasma membrane] (Mus musculus)
MDK:ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Mus musculus)
(PTN,MDK):PTPRZ [plasma membrane] (Mus musculus)
PTN,MDK [extracellular region] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
Active ALK:PI3K [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
PTPN6 dephosphorylates JAK3 (Mus musculus)
Active ALK:JAK3 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
STAT3 is phosphorylated downstream of active ALK (Mus musculus)
Active ALK dimer [plasma membrane] (Mus musculus)
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
Mdk [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P12025
Gene Names
Mdk
Reference Genes
BioGPS Gene:17242 Mdk
ENSEMBL:ENSMUSG00000027239
KEGG:mmu:17242 Mdk
Monarch:17242 Mdk
NCBI Gene:17242 Mdk
UCSC:P12025 Mdk
Reference Transcript
RefSeq:NM_001012336.2 Mdk
RefSeq:NM_010784.5 Mdk
RefSeq:NM_001012335.2 Mdk
RefSeq:NM_001291481.1 Mdk
Other Identifiers
10485070
1416006_at
160561_at
17242
17388284
4329760
4332395
4429109
4477782
4491828
4507577
4508071
4639898
4875826
5339102
5451757
5590140
A_51_P225665
A_55_P1971897
A_55_P2503910
A_66_P107379
GE42643
GO:0001662
GO:0002232
GO:0002286
GO:0002376
GO:0002690
GO:0005515
GO:0005576
GO:0006355
GO:0007010
GO:0007162
GO:0007614
GO:0008083
GO:0008201
GO:0009611
GO:0010667
GO:0010718
GO:0010759
GO:0010838
GO:0010976
GO:0010996
GO:0016477
GO:0021542
GO:0021681
GO:0021766
GO:0021987
GO:0022414
GO:0022600
GO:0030154
GO:0030279
GO:0030325
GO:0030335
GO:0030421
GO:0032330
GO:0032735
GO:0035374
GO:0035556
GO:0042246
GO:0042995
GO:0043524
GO:0044849
GO:0045582
GO:0045590
GO:0045785
GO:0045893
GO:0046850
GO:0048018
GO:0048477
GO:0048714
GO:0048856
GO:0048870
GO:0050729
GO:0050795
GO:0050877
GO:0051781
GO:0061036
GO:0071673
GO:0090023
GO:0090090
GO:0098772
GO:0106015
GO:0106016
GO:0106091
GO:1900026
GO:1903039
GO:1904036
GO:1904399
GO:1904996
GO:1905555
GO:1905564
GO:1905653
GO:2000179
GO:2000347
GO:2000391
GO:2001224
ILMN_1254450
ILMN_3079236
ILMN_3080012
ILMN_3158499
Msa.971.0_f_at
m35833_f_at
mMC017265
Participates
as a member of
PTN,MDK [extracellular region] (Mus musculus)
as a component of
MDK:p-7Y ALK dimer [plasma membrane] (Mus musculus)
MDK:ALK [plasma membrane] (Mus musculus)
MDK:ALK dimer [plasma membrane] (Mus musculus)
MDK [extracellular region] (Mus musculus)
as an input of
ALK binds ligand midkine (MDK) (Mus musculus)
Inferred From
MDK [extracellular region]
(Homo sapiens)
Cross References
ENSEMBL
ENSMUST00000090602
,
ENSMUSP00000068413
,
ENSMUSP00000028672
,
ENSMUST00000069423
,
ENSMUSP00000106941
,
ENSMUSP00000088090
,
ENSMUST00000028672
,
ENSMUST00000111309
PRO
P12025
MGI
96949
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