Reactome | CLEC4E [plasma membrane]

CLEC4E [plasma membrane]

Stable Identifier

R-MMU-2130735

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Q9R0Q8

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - C-type lectin receptors (CLRs) (Mus musculus)
    - Dectin-2 family (Mus musculus)
      - CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
      - PLCG2 translocates from cytosol to plasma membrane (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
      - SYK autophosphorylates (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
      - SYK binds to p-Y65,Y76-FCER1G (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC4E [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R0Q8

Reference Genes

BioGPS Gene:56619

ENSEMBL:ENSMUSG00000030142

ENSEMBL:ENSMUSG00000030142.11

KEGG Gene (Mus musculus):56619

Monarch:56619

NCBI Gene:56619

UCSC:Q9R0Q8

Reference Transcript

RefSeq:NM_019948.2

Other Identifiers

10547664

1420330_at

1420331_at

17470627

4346692

4349913

4363216

4656259

4873610

4889878

4920880

5081358

5139260

56619

96551_at

A_52_P161488

GE37654

GO:0001819

GO:0001891

GO:0002221

GO:0002292

GO:0002376

GO:0005509

GO:0005515

GO:0005886

GO:0006955

GO:0008289

GO:0009897

GO:0016020

GO:0023052

GO:0030154

GO:0030246

GO:0030670

GO:0031410

GO:0038023

GO:0038094

GO:0038187

GO:0042742

GO:0042995

GO:0043226

GO:0045087

GO:0046872

GO:0048856

GO:0051861

GO:0060089

GO:0061760

GO:0098542

ILMN_1215209

ILMN_1216972

ILMN_2671354

mMC018223

Participates

as a component of

Inferred From

CLEC4E [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_064332.1

Ensembl

ENSMUSP00000032239, ENSMUST00000032239, ENSMUSG00000030142

PRO

Q9R0Q8

MGI

1861232

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