Reactome | Col5a2 [extracellular region]

Col5a2 [extracellular region]

Stable Identifier

R-MMU-2127320

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

3,4-Hyp 5-Gal-Hyl collagen alpha-2(V) chain, Q3U962

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - NCAM signaling for neurite out-growth (Mus musculus)
      - NCAM1 interactions (Mus musculus)
        
        Interaction of NCAM1 with collagens (Mus musculus)
        
        Collagens [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        NCAM-1:Collagen complex [plasma membrane] (Mus musculus)
        
        Collagens [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)

Extracellular matrix organization (Mus musculus)

- Collagen formation (Mus musculus)
  - Assembly of collagen fibrils and other multimeric structures (Mus musculus)
    - Formation of collagen fibres (Mus musculus)
      - Collagen fibres [extracellular region] (Mus musculus)
        
        Collagen type V fibre [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
      - Collagen fibrils [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
    - Formation of collagen fibrils (Mus musculus)
      - Collagen fibrils [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
      - Tropocollagens [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
  - Collagen biosynthesis and modifying enzymes (Mus musculus)
    - Removal of fibrillar collagen C-propeptides (Mus musculus)
      - Tropocollagens [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
- Degradation of the extracellular matrix (Mus musculus)
  - Collagen degradation (Mus musculus)
    - Collagen type V degradation by MMP2,9,10 (Mus musculus)
      - Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
- ECM proteoglycans (Mus musculus)
  - VTN binds collagens II, III and V (Mus musculus)
    - Collagen types II, III, V [extracellular region] (Mus musculus)
      - Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
    - VTN:Collagen types II,III,V [extracellular region] (Mus musculus)
      - Collagen types II, III, V [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
- FN1 binds Collagen types I-V, VII (Mus musculus)
  - Collagen types I-V, VII [extracellular region] (Mus musculus)
    - Collagen V [extracellular region] (Mus musculus)
      - Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Mus musculus)
    - Collagen types I-V, VII [extracellular region] (Mus musculus)
      - Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
- Integrin cell surface interactions (Mus musculus)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Mus musculus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Mus musculus)
      - Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Mus musculus)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
- Non-integrin membrane-ECM interactions (Mus musculus)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Mus musculus)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Mus musculus)
      - Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Mus musculus)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Mus musculus)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Mus musculus)
      - Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Mus musculus)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by MET (Mus musculus)
    - MET promotes cell motility (Mus musculus)
      - MET activates PTK2 signaling (Mus musculus)
        
        PTK2 binds activated MET (Mus musculus)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Mus musculus)
        
        Collagen, laminin, fibronectin [extracellular region] (Mus musculus)
        
        Collagen fibres [extracellular region] (Mus musculus)
        
        Collagen type V fibre [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
  - Signaling by PDGF (Mus musculus)
    - PDGF binds to extracellular matrix proteins (Mus musculus)
      - Extracellular matrix ligands [extracellular region] (Mus musculus)
        
        Collagens [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
      - PDGF A and B chains:ECM complex [extracellular region] (Mus musculus)
        
        Extracellular matrix ligands [extracellular region] (Mus musculus)
        
        Collagens [extracellular region] (Mus musculus)
        
        Collagen V [extracellular region] (Mus musculus)
        
        Tropocollagen type V [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Mus musculus)
        
        Col5a2 [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:Q3U962

Gene Names

Col5a2

Reference Genes

BioGPS Gene:12832 Col5a2

ENSEMBL:ENSMUSG00000026042

KEGG Gene (Mus musculus):12832 Col5a2

Monarch:12832 Col5a2

NCBI Gene:12832 Col5a2

UCSC:Q3U962 Col5a2

Reference Transcript

RefSeq:NM_007737.2 Col5a2

Other Identifiers

10354309

12832

1422437_at

1450625_at

163350_at

17222719

4344854

4452250

4457969

4475864

4486011

4496291

4496299

4625236

4633411

4635797

4664898

4690773

4691061

4716476

4720720

4723020

4728054

4743329

4782178

4804213

4805100

4809269

4827635

4915263

4920445

4933920

4953413

4970420

4978452

4990729

4993630

5051652

5070828

5079880

5174153

5211076

5226364

5228620

5240032

5244103

5247350

5248875

5263796

5266653

5305718

5307750

5322485

5339711

5380451

5383805

5418830

5453585

5464196

5513910

5534770

5548206

5551919

5563211

5583540

5594075

92567_at

A_55_P2104894

GE34868

GO:0001501

GO:0001503

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005581

GO:0005588

GO:0005615

GO:0008150

GO:0009790

GO:0030020

GO:0030154

GO:0030198

GO:0030199

GO:0031012

GO:0032991

GO:0043167

GO:0043588

GO:0046332

GO:0046872

GO:0048592

GO:0048646

GO:0048856

GO:0062023

GO:0071230

GO:1903225

ILMN_1221670

ILMN_1254546

ILMN_2470069

ILMN_2802687

Msa.544.0_s_at

mMC004085

mMC008384

Participant Of

hasComponent

Other forms of this molecule

Col5a2 [endoplasmic reticulum lumen]

Col5a2 [extracellular region]

Inferred From

Collagen alpha-2(V) chains [extracellular region] (Homo sapiens)

3,4-Hyp 5-Gal-Hyl collagen alpha-2(V) chain C-term fragment [extracellular region] (Homo sapiens)

3,4-Hyp 5-Gal-Hyl collagen alpha-2(V) chain [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_031763.2

Target Pathogen

5b354852be737e166372e718

Ensembl

ENSMUST00000086430, ENSMUSG00000026042, ENSMUSP00000083620

PRO

Q3U962

MGI

88458

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