Reactome | Ago3 [cytosol]

Ago3 [cytosol]

Stable Identifier

R-MMU-210615

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

EIF2C3, Q8CJF9

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- Gene Silencing by RNA (Mus musculus)
  - MicroRNA (miRNA) biogenesis (Mus musculus)
    - Duplex miRNA is loaded into Argonaute (Mus musculus)
      - TARBP2,PRKRA RLC:duplex miRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4:duplex miRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        RISC loading complex:duplex miRNA [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
    - Removal of miRNA passenger strand (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:RISC (miRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:RISC (miRNA) [cytosol] (Mus musculus)
        
        RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO3:miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:RISC (miRNA) [cytosol] (Mus musculus)
        
        RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO3:miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
  - Post-transcriptional silencing by small RNAs (Mus musculus)
    - Nonendonucleolytic RISC binds exactly matching target RNAs (Mus musculus)
      - Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO3:miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        AGO3:siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
      - TNRC6:Nonendonucleolytic RISC:Target RNA (exact match) [cytosol] (Mus musculus)
        
        Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO3:miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        AGO3:siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
    - RISC binds inexactly matching target RNAs (Mus musculus)
      - RISC [cytosol] (Mus musculus)
        
        Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO3:miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        AGO3:siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
      - TNRC6:RISC:Target RNA (inexact match) [cytosol] (Mus musculus)
        
        RISC [cytosol] (Mus musculus)
        
        Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO3:miRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        AGO3:siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
  - Small interfering RNA (siRNA) biogenesis (Mus musculus)
    - Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Mus musculus)
      - TARBP2,PRKRA RLC [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
      - TARBP2,PRKRA RLC:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        RISC loading complex:duplex siRNA [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
    - Duplex siRNA is loaded into Argonaute (Mus musculus)
      - TARBP2,PRKRA RLC:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        RISC loading complex:duplex siRNA [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
    - Removal of siRNA passenger strand (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO3:duplex siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:RISC (siRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:RISC (siRNA) [cytosol] (Mus musculus)
        
        RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO3:siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:RISC (siRNA) [cytosol] (Mus musculus)
        
        RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO3:siRNA [cytosol] (Mus musculus)
        
        Ago3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CJF9

Gene Names

Ago3

Reference Genes

BioGPS Gene:214150 Ago3

ENSEMBL:ENSMUSG00000028842

KEGG Gene (Mus musculus):214150 Ago3

Monarch:214150 Ago3

NCBI Gene:214150 Ago3

UCSC:Q8CJF9 Ago3

Reference Transcript

RefSeq:NM_153402.2 Ago3

Other Identifiers

103684_at

10516335

10516348

105772_at

111101_at

136009_at

1418484_at

1435904_at

1441063_at

1441089_at

1442009_at

1458476_at

17430037

17430052

214150

4308249

4318928

4344398

4377838

4412396

4422025

4422824

4439189

4458197

4470838

4494569

4503977

4536360

4574403

4585442

4589557

4600391

4612014

4620848

4629035

4661573

4662785

4685697

4692842

4723094

4763777

4765961

4775391

4787000

4824286

4831607

4861034

4867805

4880868

4881940

4944827

4949912

4967248

4975378

5020056

5049281

5071741

5086307

5101302

5104099

5108301

5138373

5152574

5173452

5182658

5209207

5209891

5229766

5232483

5240026

5244249

5257804

5273663

5317722

5322284

5381178

5410301

5432875

5449156

5471597

5487016

5495390

5507732

5534091

5567207

5569541

5593514

5617172

A_51_P109933

A_51_P113068

A_52_P126513

A_52_P126521

A_52_P24793

A_52_P556266

A_55_P2068922

A_55_P2132014

GE1418347

GE1506757

GO:0000228

GO:0000794

GO:0000932

GO:0003674

GO:0003676

GO:0003723

GO:0003725

GO:0003727

GO:0004518

GO:0004519

GO:0004521

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006402

GO:0006412

GO:0006417

GO:0007165

GO:0008150

GO:0008283

GO:0009056

GO:0009058

GO:0010501

GO:0010628

GO:0016442

GO:0016787

GO:0022607

GO:0022618

GO:0031047

GO:0031054

GO:0032991

GO:0034641

GO:0034655

GO:0035196

GO:0035198

GO:0035278

GO:0035279

GO:0035280

GO:0036464

GO:0043167

GO:0043226

GO:0046872

GO:0065003

GO:0070578

GO:0072091

GO:0090305

GO:0090502

GO:0090624

GO:1901224

ILMN_1225641

ILMN_1233354

ILMN_2596744

ILMN_2634914

ILMN_2642288

ILMN_2870191

mMC008977

mMC013522

mMC015969

mMR027592

Participant Of

hasComponent

hasCandidate

AGO1,2,3,4 [cytosol]

hasMember

Nonendonucleolytic Argonaute [cytosol]

Inferred From

EIF2C3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_700451.2

Ensembl

ENSMUSP00000066633, ENSMUSG00000028842, ENSMUST00000069097

PRO

Q8CJF9

MGI

2446634

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