Reactome | Ago4 [cytosol]

Ago4 [cytosol]

Stable Identifier

R-MMU-210612

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

EIF2C4, Q8CJF8

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- Gene Silencing by RNA (Mus musculus)
  - MicroRNA (miRNA) biogenesis (Mus musculus)
    - Duplex miRNA is loaded into Argonaute (Mus musculus)
      - TARBP2,PRKRA RLC:duplex miRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4:duplex miRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        RISC loading complex:duplex miRNA [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
    - Removal of miRNA passenger strand (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        pre-RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:RISC (miRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:RISC (miRNA) [cytosol] (Mus musculus)
        
        RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO4:miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:RISC (miRNA) [cytosol] (Mus musculus)
        
        RISC (miRNA) [cytosol] (Mus musculus)
        
        AGO4:miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
  - Post-transcriptional silencing by small RNAs (Mus musculus)
    - Nonendonucleolytic RISC binds exactly matching target RNAs (Mus musculus)
      - Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO4:miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        AGO4:siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
      - TNRC6:Nonendonucleolytic RISC:Target RNA (exact match) [cytosol] (Mus musculus)
        
        Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO4:miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        AGO4:siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
    - RISC binds inexactly matching target RNAs (Mus musculus)
      - RISC [cytosol] (Mus musculus)
        
        Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO4:miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        AGO4:siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
      - TNRC6:RISC:Target RNA (inexact match) [cytosol] (Mus musculus)
        
        RISC [cytosol] (Mus musculus)
        
        Nonendonucleolytic RISC [cytosol] (Mus musculus)
        
        AGO4:miRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        AGO4:siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
  - Small interfering RNA (siRNA) biogenesis (Mus musculus)
    - Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Mus musculus)
      - TARBP2,PRKRA RLC [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
      - TARBP2,PRKRA RLC:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        RISC loading complex:duplex siRNA [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
    - Duplex siRNA is loaded into Argonaute (Mus musculus)
      - TARBP2,PRKRA RLC:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4:duplex siRNA [cytosol] (Mus musculus)
        
        PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        RISC loading complex:duplex siRNA [cytosol] (Mus musculus)
        
        RISC loading complex [cytosol] (Mus musculus)
        
        AGO1,2,3,4 [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
    - Removal of siRNA passenger strand (Mus musculus)
      - TARBP2,PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:Pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        pre-RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO4:duplex siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
      - TARBP2,PRKRA:DICER1:RISC (siRNA) [cytosol] (Mus musculus)
        
        PRKRA:DICER1:RISC (siRNA) [cytosol] (Mus musculus)
        
        RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO4:siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)
        
        TARBP2:DICER1:RISC (siRNA) [cytosol] (Mus musculus)
        
        RISC (siRNA) [cytosol] (Mus musculus)
        
        AGO4:siRNA [cytosol] (Mus musculus)
        
        Ago4 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CJF8

Gene Names

Ago4

Reference Genes

BioGPS Gene:76850 Ago4

ENSEMBL:ENSMUSG00000042500

KEGG Gene (Mus musculus):76850 Ago4

Monarch:76850 Ago4

NCBI Gene:76850 Ago4

UCSC:Q8CJF8 Ago4

Reference Transcript

RefSeq:NM_153177.3 Ago4

Other Identifiers

10516393

137475_at

1429779_at

1453289_at

17430103

4310818

4404313

4418977

4491697

4521792

4567047

4606470

4658740

4676382

4732442

4754950

4812691

4827498

4860216

4872218

4970969

4971366

4989353

5013663

5075904

5090896

5108415

5145459

5305708

5332000

5415254

5428920

5503263

5569810

76850

A_52_P17422

A_52_P27122

A_52_P525027

A_52_P8444

A_55_P2113071

GE1536244

GO:0000003

GO:0000902

GO:0000932

GO:0003674

GO:0003676

GO:0003723

GO:0003725

GO:0003727

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0006402

GO:0006412

GO:0006417

GO:0007049

GO:0007059

GO:0007130

GO:0007140

GO:0008150

GO:0008219

GO:0008584

GO:0009056

GO:0009058

GO:0010501

GO:0010586

GO:0016442

GO:0022604

GO:0022607

GO:0022618

GO:0031047

GO:0031054

GO:0032991

GO:0034641

GO:0034655

GO:0035196

GO:0035198

GO:0035278

GO:0035280

GO:0043066

GO:0043226

GO:0048856

GO:0051276

GO:0065003

GO:0070578

ILMN_1219109

ILMN_1246761

mMC015912

mMR030546

Participant Of

hasComponent

hasCandidate

AGO1,2,3,4 [cytosol]

hasMember

Nonendonucleolytic Argonaute [cytosol]

Inferred From

EIF2C4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_694817.2

Ensembl

ENSMUSP00000081312, ENSMUSG00000042500, ENSMUST00000084289

PRO

Q8CJF8

MGI

1924100

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