Itch ubiquitinates Notch

Stable Identifier
R-MMU-2077479
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Itch ubiquitinates Notch
Numb mediated degradation of Notch1 depends on the presence of an Itch-interacting domain of Numb (McGill et al. 2009). This was shown by expressing exogenous recombinant mouse Notch1, Numb and Itch in human embryonic kidney cell line HEK293 and mouse myogenic cell line C2C12. In support of this, recombinant human ITCH was shown to associate with recombinant mouse Notch1 indirectly and ubiquitinate it, in the absence of ligand, targeting it for degradation (Chastagner et al. 2008).
Literature References
PubMed ID Title Journal Year
19567869 Numb regulates post-endocytic trafficking and degradation of Notch1

McGill, MA, McGlade, CJ, Weinmaster, G, Dho, SE

J Biol Chem 2009
Participants
Input
Output
Orthologous Events
Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-28)
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