Reactome | BTRC:CUL1:RBX1:SKP1 [cytosol]

BTRC:CUL1:RBX1:SKP1 [cytosol]

Stable Identifier

R-MMU-206748

Type

Complex

Species

Mus musculus

Compartment

cytosol

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Cul1 [cytosol] (Mus musculus)
Ghost homologue of BTRC [cytosol] (Mus musculus)
RBX1 [cytosol] (Mus musculus)
Skp1 [cytosol] (Mus musculus)

Participates

as an output of

Prolactin receptor is internalized (Mus musculus)
Degradation of ubiquitinated beta catenin by the proteasome (Mus musculus)

as an input of

PRLR binds SCF beta-TrCP complex (Mus musculus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Mus musculus)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)

as a component of

RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Mus musculus)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Mus musculus)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Mus musculus)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Mus musculus)

Inferred From

BTRC:CUL1:RBX1:SKP1 [cytosol] (Homo sapiens)

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