Dll4 binds Notch1

Stable Identifier
R-MMU-2053938
Type
Reaction
Species
Mus musculus
Compartment
General
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Dll4 binds Notch1

Cultured mouse endothelial cells expressing Notch1 are activated by immobilized mouse Dll4, and activation by Dll4 is enhanced when Notch1 is modified by manic fringe (Mfng). The activation of Notch1 by Dll4 and positive effect of fringe-mediated Notch1 modification on this interaction are confirmed by a co-culture assay in which Dll4-expressing cells are mixed with Notch1-expressing cells (with or without Mfng) transfected with the Notch reporter construct.

Literature References
PubMed ID Title Journal Year
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Roca, C, Sörensen, I, Adams, S, Gossler, A, Fruttiger, M, Adams, RH

Cell 2009
Participants
Orthologous Events
Authored
Reviewed
Created