Dll4 binds Notch1

Stable Identifier
R-MMU-2053938
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dll4 binds Notch1
Cultured mouse endothelial cells expressing Notch1 are activated by immobilized mouse Dll4, and activation by Dll4 is enhanced when Notch1 is modified by manic fringe (Mfng). The activation of Notch1 by Dll4 and positive effect of fringe-mediated Notch1 modification on this interaction are confirmed by a co-culture assay in which Dll4-expressing cells are mixed with Notch1-expressing cells (with or without Mfng) transfected with the Notch reporter construct.
Literature References
PubMed ID Title Journal Year
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Adams, S, Gossler, A, Adams, RH, Fruttiger, M, Roca, C, Sörensen, I

Cell 2009
Participants
Input
Output
Entity On Other Cell
Orthologous Events
NOTCH1 binds DLL4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-12)
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