NGF:p75NTR complex binds to Nrage

Stable Identifier
R-MMU-204967
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
NGF:p75NTR complex binds to Nrage

NRAGE (neurotrophin receptor-interacting MAGE homolog), a member of the MAGE family of proteins, is a cytoplasmic protein that mediates neurotrophin-induced cell death. NRAGE binding is stimulated following NGF (or proNGF) binding to p75NTR. Some studies indicate that NRAGE expression is limited to proliferative neural populations, whereas others indicate its presence in differentiated neurons in hippocampus. Another MAGE protein, Necdin, was reported to interact with p75NTR and affect cell death.

Literature References
PubMed ID Title Journal Year
10985348 NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis

Salehi, AH, Roux, PP, Kubu, CJ, Zeindler, C, Bhakar, A, Tannis, LL, Verdi, JM, Barker, PA

Neuron 2000
Participants
Orthologous Events
Authored
Reviewed
Created
Cite Us!