Reactome | Igkv8-21 [plasma membrane]

Igkv8-21 [plasma membrane]

Stable Identifier

R-MMU-2038795

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

IGKV4-1(21-?), A0A140T8P7

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Signaling by the B Cell Receptor (BCR) (Mus musculus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
      - BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
        
        BLNK (SLP-65) Signalosome [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - BTK binds BTK inhibitors (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        BTK:BTK inhibitors [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - SYK autophosphorylates at the activated BCR (Mus musculus)
        
        Antigen:p-BCR:SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - SYK binds the activated BCR (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - The Immunoglobulin of the BCR binds antigen (Mus musculus)
        
        Antigen:BCR [plasma membrane] (Mus musculus)
        
        BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR:p-SYK [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
    - CD22 mediated BCR regulation (Mus musculus)
      - CD22 binds B-cell receptor (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - LYN phosphorylates CD22 (Mus musculus)
        
        CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
      - SHP1 binds p-CD22 (Mus musculus)
        
        PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        Antigen:p-BCR [plasma membrane] (Mus musculus)
        
        p-BCR [plasma membrane] (Mus musculus)
        
        IgM or IgD [plasma membrane] (Mus musculus)
        
        IgD [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)
        
        IgM [plasma membrane] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [plasma membrane] (Mus musculus)
        
        Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)
        
        Igkv8-21 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:A0A140T8P7

Gene Names

Igkv8-21

Reference Genes

ENSEMBL:ENSMUSG00000076586

ENSEMBL:ENSMUSG00000076586.3 Igkv8-21

Other Identifiers

101331_f_at

10545239

17467537

4477372

4788003

4949918

5003775

5006521

5565327

A_66_P105250

GO:0002376

GO:0005576

GO:0005615

GO:0006955

ILMN_2510884

Participates

as a member of

Ig Kappa Light Chain V Region [plasma membrane] (Mus musculus)

Other forms of this molecule

Igkv8-21 [extracellular region]

Inferred From

IGKV4-1(21-?) [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSMUST00000103387, ENSMUSG00000076586, ENSMUSP00000100188

MGI

1330840

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