Jag2 binds Notch2

Stable Identifier
R-MMU-2032379
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
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Jag2 binds Notch2

Mouse Jag2 exogenously expressed on the surface of Chinese hamster ovary (CHO) cells binds Notch2, a predominant Notch protein on the surface of mouse BaF3 cells, inducing Notch2 cleavage and translocation of Notch2 intracellular domain (NICD2) to the nucleus (Shimizu et al. 2000).

Literature References
PubMed ID Title Journal Year
10958687 Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

Shimizu, K, Chiba, S, Hosoya, N, Kumano, K, Saito, T, Kurokawa, M, Kanda, Y, Hamada, Y, Hirai, H

Mol Cell Biol 2000
Participants
Orthologous Events
Authored
Reviewed
Created
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