Reactome | Dctn4 [cytosol]

Dctn4 [cytosol]

Stable Identifier

R-MMU-2029070

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

DCTN4, Q8CBY8

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Transport of antigen loaded MHC II molecules to surface (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
      - Kinesins:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPI-mediated anterograde transport (Mus musculus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPI-mediated anterograde transport (Mus musculus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
    - Golgi-to-ER retrograde transport (Mus musculus)
      - COPI-independent Golgi-to-ER retrograde traffic (Mus musculus)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn4 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CBY8

Gene Names

Dctn4

Reference Genes

BioGPS Gene:67665 Dctn4

ENSEMBL:ENSMUSG00000024603

ENSEMBL:ENSMUSG00000024603.9 Dctn4

KEGG Gene (Mus musculus):67665 Dctn4

Monarch:67665 Dctn4

NCBI Gene:67665 Dctn4

UCSC:Q8CBY8 Dctn4

Reference Transcript

Other Identifiers

10455974

110721_at

1420861_at

1420862_at

1420863_at

1450030_at

163501_at

17350936

4325021

4571148

4726932

4757069

4814235

4869269

4876826

4968478

5005308

5009085

5019194

5143699

5199250

5202135

5313482

5357264

5434590

5440786

5504363

5605359

67665

A_51_P219858

A_52_P201627

A_55_P2015238

A_55_P2120773

A_66_P139328

GE41183

GO:0000776

GO:0000922

GO:0001725

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0005868

GO:0005869

GO:0005925

GO:0005938

GO:0030017

GO:0043226

ILMN_2630293

ILMN_2630294

ILMN_2712305

mMC023504

mMR031034

Participates

as a component of

Pointed end complex [cytosol] (Mus musculus)

Inferred From

DCTN4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006526252.1, NP_080578.1

Ensembl

ENSMUST00000223984, ENSMUSG00000024603, ENSMUSP00000153008, ENSMUSP00000025505, ENSMUST00000025505

PRO

Q8CBY8

MGI

1914915

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