Reactome | Dctn5 [cytosol]

Dctn5 [cytosol]

Stable Identifier

R-MMU-2029012

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

DCTN5, Q9QZB9

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Transport of antigen loaded MHC II molecules to surface (Mus musculus)
      - Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
      - Kinesins:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPI-mediated anterograde transport (Mus musculus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPI-mediated anterograde transport (Mus musculus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
    - Golgi-to-ER retrograde transport (Mus musculus)
      - COPI-independent Golgi-to-ER retrograde traffic (Mus musculus)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Mus musculus)
        
        Dynein:Dynactin:microtubule [cytosol] (Mus musculus)
        
        Dynactin [cytosol] (Mus musculus)
        
        Dynactin rod [cytosol] (Mus musculus)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Mus musculus)
        
        Pointed end complex [cytosol] (Mus musculus)
        
        Dctn5 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QZB9

Gene Names

Dctn5

Reference Genes

BioGPS Gene:59288 Dctn5

ENSEMBL:ENSMUSG00000030868

KEGG:mmu:59288 Dctn5

Monarch:59288 Dctn5

NCBI Gene:59288 Dctn5

UCSC:Q9QZB9 Dctn5

Reference Transcript

RefSeq:NM_021608.3 Dctn5

Other Identifiers

10339161

10339666

10344389

10557148

1415748_a_at

1458247_s_at

17208727

17208729

17208731

17208733

17208735

17208737

17482730

4423690

4591180

4600905

4734719

4926255

4931564

5008242

5026366

5056982

5068057

5120111

5133917

5156312

5233204

5275030

59288

96636_at

A_51_P201841

A_52_P387954

A_52_P474739

GE38059

GO:0000775

GO:0000776

GO:0003281

GO:0003674

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0005869

GO:0031965

GO:0035904

GO:0043226

GO:0048856

GO:0060976

ILMN_2732536

aa110732_s_at

mMC007877

Participates

as a component of

Pointed end complex [cytosol] (Mus musculus)

Inferred From

DCTN5 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSG00000030868, ENSMUST00000033156, ENSMUSP00000033156

PRO

Q9QZB9

GlyGen

Q9QZB9

MGI

1891689

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