Calcineurin Dephosphorylates Nfatc2

Stable Identifier
R-MMU-2025936
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
General
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Calcineurin Dephosphorylates Nfatc2

Calcineurin dephosposphrylates multiple residues on Nfat2 which results in translocation of Nfat2 to the nucleus.

Literature References
PubMed ID Title Journal Year
7889407 Cyclosporin-A sensitive induction of NF-AT in murine B cells

Venkataraman, L, Francis, DA, Wang, Z, Liu, J, Rothstein, TL, Sen, R

Immunity 1994
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Okamura, H, Aramburu, J, García-Rodríguez, C, Viola, JP, Raghavan, A, Tahiliani, M, Zhang, X, Qin, J, Hogan, PG, Rao, A

Mol Cell 2000
7545680 Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody

Ruff, VA, Leach, KL

J Biol Chem 1995
7479966 Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells

Shaw, KT, Ho, AM, Raghavan, A, Kim, J, Jain, J, Park, J, Sharma, S, Rao, A, Hogan, PG

Proc Natl Acad Sci U S A 1995
8397339 The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

Jain, J, McCaffrey, PG, Miner, Z, Kerppola, TK, Lambert, JN, Verdine, GL, Curran, T, Rao, A

Nature 1993
Participants
Catalyst Activity
Catalyst Activity
Title
calcium-dependent protein serine/threonine phosphatase activity of Calcineurin:Phosphorylated Nfatc2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created