Active NTRK1 binds IRS1/2

Stable Identifier
R-MMU-198275
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Active NTRK1 binds IRS1/2

IRS1 and IRS2 bind directly to TRK receptors phosphorylated at Y490, through their phosphotyrosine- binding (PTB) domains.

Literature References
PubMed ID Title Journal Year
11147812 IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1

Van Obberghen, E, Miele, C, Miranda, C, Greco, A, Pierotti, MA

J Cell Physiol 2001
Participants
Orthologous Events
Reviewed
Created
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