Reactome | Fcgr1 [plasma membrane]

Fcgr1 [plasma membrane]

Stable Identifier

R-MMU-197835

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

FCGR1A, P26151

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing-Cross presentation (Mus musculus)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Mus musculus)
        
        Internalization of receptor bound antigen into clathrin coted vesicles (Mus musculus)
        
        MR:soluble antigen [plasma membrane] (Mus musculus)
        
        MR/other probable receptors [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - FCGR activation (Mus musculus)
      - Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Mus musculus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Recruitment of SYK to phosphorylated ITAMs (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)
        
        clustered IgG-Ag:FCGRs [plasma membrane] (Mus musculus)
        
        FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:CD3G homodimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Activation of RAC1 by VAV (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Phosphorylation of VAV (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Role of myosins in phagosome formation (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
    - Role of phospholipids in phagocytosis (Mus musculus)
      - PI3K binds to p-6Y-SYK (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Phosphorylation and activation of PLCG (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Recruitment of PLCgamma to membrane (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
      - Release of PLCG from FCGR (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        p-FCGRs [plasma membrane] (Mus musculus)
        
        FCGRIA:p-Y160,Y171-CD3G dimer [plasma membrane] (Mus musculus)
        
        Fcgr1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P26151

Gene Names

Fcgr1

Reference Genes

BioGPS Gene:14129 Fcgr1

CTD Gene:14129 Fcgr1

ENSEMBL:ENSMUSG00000015947

ENSEMBL:ENSMUSG00000015947.11 Fcgr1

KEGG Gene (Mus musculus):14129 Fcgr1

Monarch:14129 Fcgr1

NCBI Gene:14129 Fcgr1

UCSC:P26151 Fcgr1

Reference Transcript

RefSeq:NM_010186.5 Fcgr1

Other Identifiers

101793_at

102879_s_at

10500335

14129

1417876_at

1436625_at

166960_f_at

17408024

4366455

4382045

4452822

4502391

4717069

4721556

4733439

4796386

4801881

4873807

5028815

5254046

5330512

5355221

5527724

A_51_P296755

A_51_P296764

A_55_P2008740

GE35391

GO:0001788

GO:0001798

GO:0001805

GO:0002376

GO:0004888

GO:0005886

GO:0006898

GO:0006910

GO:0006911

GO:0006954

GO:0007166

GO:0009617

GO:0009897

GO:0016020

GO:0016192

GO:0019770

GO:0019771

GO:0019864

GO:0019884

GO:0023052

GO:0031774

GO:0038094

GO:0042590

GO:0042742

GO:0045087

GO:0050766

GO:0050776

GO:0060089

GO:0060100

GO:0061024

GO:0098542

ILMN_1229523

M31314_s_at

mMC016416

Participates

as a member of

MR/other probable receptors [plasma membrane] (Mus musculus)

as a component of

Other forms of this molecule

Fcgr1 [clathrin-coated endocytic vesicle membrane]

Fcgr1 [early endosome membrane]

Inferred From

FCGRA [plasma membrane] (Homo sapiens)

FCGR1A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_034316.1

Ensembl

ENSMUST00000029748, ENSMUSP00000029748, ENSMUSG00000015947

PRO

P26151

MGI

95498

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