Reactome | Iglc2 [extracellular region]

Iglc2 [extracellular region]

Stable Identifier

R-MMU-197041-2

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

IGKC, P01844

Locations in the PathwayBrowser

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Hemostasis (Mus musculus)

- Cell surface interactions at the vascular wall (Mus musculus)
  - FCAMR binds IgA (Mus musculus)
    - 2xIgA:JCHAIN [extracellular region] (Mus musculus)
      - IgA [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - FCAMR:2xIgA:JCHAIN [plasma membrane] (Mus musculus)
      - 2xIgA:JCHAIN [extracellular region] (Mus musculus)
        
        IgA [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Mus musculus)
    - Fc gamma receptors interact with antigen-bound IgG (Mus musculus)
      - Antigen-bound Ig G Antibody [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Antigen-bound antibody bound to lymphoid Fc gamma receptors [plasma membrane] (Mus musculus)
        
        Antigen-bound Ig G Antibody [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Complement cascade (Mus musculus)
    - Initial triggering of complement (Mus musculus)
      - Conversion of C2 into C2a and C2b (Mus musculus)
        
        C4 activators [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Conversion of C4 into C4a and C4b (Mus musculus)
        
        C4 activators [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Creation of C4 and C2 activators (Mus musculus)
        
        Classical antibody-mediated complement activation (Mus musculus)
        
        Activation of C1r (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        Activation of C1s (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - Regulation of Complement cascade (Mus musculus)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - C1-Inh binds and inactivates C1r, C1s (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - Allergen dependent IgE bound FCERI aggregation (Mus musculus)
      - FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - FCERI mediated Ca+2 mobilization (Mus musculus)
      - Phosphorylation of TEC kinases by p-SYK (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - Phosphorylation of SHC by SYK kinase (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - FCERI mediated NF-kB activation (Mus musculus)
      - Phosphorylation of PKC-theta (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - IgE binds FCERI (Mus musculus)
      - FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - IgE binds omalizumab (Mus musculus)
      - IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - IgE:omalizumab [extracellular region] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - Phosphorylation of LAT by p-SYK (Mus musculus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - Phosphorylation of beta and gamma subunits by LYN (Mus musculus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        FCERI:IgE [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
      - Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Mus musculus)
        
        IgE [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - FCGR activation (Mus musculus)
      - Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        IgG-Ag:FCGRIIA [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        IgG-Ag:FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Recruitment of SYK to phosphorylated ITAMs (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)
        
        clustered IgG-Ag:FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Activation of RAC1 by VAV (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Phosphorylation of VAV (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Role of myosins in phagosome formation (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
    - Role of phospholipids in phagocytosis (Mus musculus)
      - PI3K binds to p-6Y-SYK (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Phosphorylation and activation of PLCG (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Recruitment of PLCgamma to membrane (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - Release of PLCG from FCGR (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Binding and Uptake of Ligands by Scavenger Receptors (Mus musculus)
  - Scavenging of heme from plasma (Mus musculus)
    - Alpha-1-Microglobulin is cleaved (Mus musculus)
      - 2xIgA:JCHAIN [extracellular region] (Mus musculus)
        
        IgA [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)
      - IgA:Alpha-1-Microglobulin [extracellular region] (Mus musculus)
        
        2xIgA:JCHAIN [extracellular region] (Mus musculus)
        
        IgA [extracellular region] (Mus musculus)
        
        Immunoglobulin Kappa Light Chain [extracellular region] (Mus musculus)
        
        Homologues of IGKC [extracellular region] (Mus musculus)
        
        Iglc2 [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P01844 Iglc2

Gene Names

Iglc2

Chain

chain:1-104

Reference Genes

ENSEMBL:ENSMUSG00000076937.4 Iglc2

Other Identifiers

1428719_at

1428720_s_at

1447918_x_at

163884_f_at

164859_f_at

17329016

4320694

4546059

4749363

4956120

5048722

5067127

5165594

92316_f_at

A_51_P235015

A_55_P2057283

GE1507275

GO:0002376

GO:0003823

GO:0005576

GO:0005886

GO:0016064

GO:0071735

Participates

as a member of

Homologues of IGKC [extracellular region] (Mus musculus)

Other forms of this molecule

Ig lambda-2 chain C region [plasma membrane]

Iglc2 [plasma membrane]

Iglc2 [extracellular region]

Inferred From

IGKC [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSMUSG00000076937, ENSMUST00000103749, ENSMUSP00000100464

PRO

P01844

MGI

99547

PDB

2QHR

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