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NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane]
Stable Identifier
R-MMU-1963583
Type
Complex
Species
Mus musculus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
ERBB2 Activates PTK6 Signaling (Mus musculus)
Activated ERBB2 binds PTK6 (BRK) (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 promotes PTK6 autophosphorylation (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
Downregulation of ERBB2:ERBB3 signaling (Mus musculus)
RNF41 binds neuregulin-activated ERBB3 (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
RNF41 ubiquitinates activated ERBB3 (Mus musculus)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MATK [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Mus musculus)
Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 Activates PTK6 Signaling (Mus musculus)
Activated ERBB2 binds PTK6 (BRK) (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 promotes PTK6 autophosphorylation (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 Regulates Cell Motility (Mus musculus)
MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
GRB7 events in ERBB2 signaling (Mus musculus)
GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
SHC1 events in ERBB2 signaling (Mus musculus)
SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
NRG1/2:p-10Y-ERBB3 [plasma membrane]
(Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane]
(Mus musculus)
Participates
as a member of
Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
Inferred From
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane]
(Homo sapiens)
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