Reactome | Actb [plasma membrane]

Actb [plasma membrane]

Stable Identifier

R-MMU-196016

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

ACTB(1-375), P60710

Locations in the PathwayBrowser

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Cell-Cell communication (Mus musculus)

- Cell junction organization (Mus musculus)
  - Cell-cell junction organization (Mus musculus)
    - Adherens junctions interactions (Mus musculus)
      - ANG binds F-actin (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        F-actin:ANG [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Dissociation of RAS:RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        RAF phosphorylates MAP2K dimer (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - Dissociation of clathrin-associated proteins (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - RAB5 and GAPVD1 bind AP-2 (Mus musculus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - SNX9 recruits components of the actin polymerizing machinery (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        f-actin [plasma membrane] (Mus musculus)
        
        actin:ATP [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
  - Gap junction trafficking and regulation (Mus musculus)
    - Gap junction trafficking (Mus musculus)
      - Gap junction degradation (Mus musculus)
        
        Formation of annular gap junctions (Mus musculus)
        
        Dab2 is recruited to the junctional plaques (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        Dynamin is recruited to the gap junction plaque (Mus musculus)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)
        
        Internalization of gap junction plaques (Mus musculus)
        
        Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Mus musculus)
        
        planar gap junction plaques associated with Dab2 [plasma membrane] (Mus musculus)
        
        planar gap junction plaques [plasma membrane] (Mus musculus)
        
        F-actin [plasma membrane] (Mus musculus)
        
        actin [plasma membrane] (Mus musculus)
        
        Actb [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P60710 Actb

Gene Names

Actb

Chain

initiator methionine:1, chain:1-375, chain:2-375

Reference Genes

BioGPS Gene:11461 Actb

ENSEMBL:ENSMUSG00000029580 Actb

KEGG Gene (Mus musculus):11461 Actb

Monarch:11461 Actb

NCBI Gene:11461 Actb

UCSC:P60710 Actb

Reference Transcript

RefSeq:NM_007393.5 Actb

Other Identifiers

101578_f_at

10535381

11461

1419734_at

1436722_a_at

17454753

4364422

4373906

4394707

4466605

4499999

4579816

4621798

4758435

4843731

4894310

4900596

5037780

5164938

5437641

5469001

5476102

5516083

95705_s_at

AA590859_f_at

AA709861_f_at

AFFX-b-ActinMur/M12481_3_at

AFFX-b-ActinMur/M12481_5_at

AFFX-b-ActinMur/M12481_M_at

A_51_P173760

A_55_P2112737

GE33405

ILMN_1377923

ILMN_2588055

ILMN_2617433

ILMN_2698799

ILMN_2743360

ILMN_2846865

j04181_f_at

mMC022518

Participates

as a member of

actin [plasma membrane] (Mus musculus)

as a candidate of

actin [plasma membrane] (Mus musculus)

Other forms of this molecule

Actb [lysosomal membrane]

Actb [nucleoplasm]

Actin, cytoplasmic 1 [cytosol]

Inferred From

ACTB(1-375) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_031419.1

Target Pathogen

57c0a8ffbe737e1cc0a9b110, 5b354852be737e166372e7d7, 5b2801b2be737e35a6deb0f8, 57c09dcebe737e1cc0a98e2f, 5b2801b2be737e35a6debb27, 57c09dcebe737e1cc0a98de3, 57c09dcebe737e1cc0a98e30, 5b354852be737e166372e752, 57c09dcebe737e1cc0a98ddf, 5b354852be737e166372e7cc, 5b354852be737e166372e763

Ensembl

ENSMUSG00000029580, ENSMUSP00000098066, ENSMUST00000100497

PRO

P60710

MGI

87904

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P97792	1	Cxadr [plasma membrane] (R-MMU-197912)	0.672	6
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.643	4
UniProt:Q923J1	1	Trpm7 [plasma membrane] (R-MMU-937281)	0.564	2
UniProt:Q5S006	1	Lrrk2 [cytosol] (R-MMU-5661173)	0.527	2
UniProt:P16054	2	phospho-Prkce [plasma membrane] (R-MMU-198260) Prkce [cytosol] (R-MMU-58202)	0.524	2

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