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About
What is Reactome ?
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Digital Preservation
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Activated FGFR4 homodimer [plasma membrane]
Stable Identifier
R-MMU-190328
Type
Complex
Species
Mus musculus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by FGFR (Mus musculus)
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
FRS-mediated FGFR4 signaling (Mus musculus)
Activated FGFR4 binds FRS2 (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4 binds FRS3 (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4 phosphorylates FRS2 (Mus musculus)
Activated FGFR4:FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4 phosphorylates FRS3 (Mus musculus)
Activated FGFR4:FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4 phosphorylates PPTN11 (Mus musculus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS3 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
PI-3K cascade:FGFR4 (Mus musculus)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Phospholipase C-mediated cascade; FGFR4 (Mus musculus)
Activated FGFR4 binds PLCG1 (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
activated FGFR4:PLCG1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4 phosphorylates PLCG1 (Mus musculus)
activated FGFR4:PLCG1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
SHC-mediated cascade:FGFR4 (Mus musculus)
Activated FGFR4 binds SHC1 (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:SHC1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4 phosphorylates SHC1 (Mus musculus)
Activated FGFR4:SHC1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Mus musculus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
Activated FGFR4:pY-SHC1 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
FGFR4 ligand binding and activation (Mus musculus)
Autocatalytic phosphorylation of FGFR4 (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Negative regulation of FGFR4 signaling (Mus musculus)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Mus musculus)
Activated FGFR4:FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
CBL ubiquitinates FRS2 and FGFR4 (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR4:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
Activated FGFR bound to PI3K [cytosol] (Mus musculus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
Activated FGFR bound to PI3K [cytosol] (Mus musculus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Mus musculus)
Activated FGFR:p-FRS2 [plasma membrane] (Mus musculus)
Activated FGFR [plasma membrane] (Mus musculus)
Activated FGFR4 homodimer [plasma membrane] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
FGFR4-binding FGFs [extracellular region]
(Mus musculus)
HS [extracellular region]
x 2
phospho-Fgfr4 [plasma membrane]
(Mus musculus)
Participates
as a member of
Activated FGFR [plasma membrane] (Mus musculus)
Activated FGFR4 [plasma membrane] (Mus musculus)
as an output of
Autocatalytic phosphorylation of FGFR4 (Mus musculus)
Inferred From
Activated FGFR4 homodimer [plasma membrane]
(Homo sapiens)
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