FGF10 activates Pdx1 expression in the developing early pancreatic bud

Stable Identifier
R-MMU-190088
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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FGF10 activates Pdx1 expression in the developing early pancreatic bud

Double Fgf10/Hnf6 KO studies have shown that these two proteins play redundant roles in the maintenance of Pdx1 expression in the early pancreatic bud. Thus, while Hnf6 KO embryos have delayed expression of Pdx1, and Fgf10-deficient embryos have only a partial reduction in the Pdx1, Fgf10/Hnf6 double mutant embryos fail to generate pancreatic buds.

Literature References
PubMed ID Title Journal Year
11748146 Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis

Bhushan, A, Itoh, N, Kato, S, Thiery, JP, Czernichow, P, Bellusci, S, Scharfmann, R

Development 2001
16386727 An endothelial-mesenchymal relay pathway regulates early phases of pancreas development

Jacquemin, P, Yoshitomi, H, Kashima, Y, Rousseau, GG, Lemaigre, FP, Zaret, KS

Dev Biol 2006
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