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Cul1 [nucleoplasm]
Stable Identifier
R-MMU-187551
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
CUL1, Q9WTX6
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G1 Phase (Mus musculus)
Cyclin D associated events in G1 (Mus musculus)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
G1/S Transition (Mus musculus)
Cyclin E associated events during G1/S transition (Mus musculus)
SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
Association of Cks1 with SCF(Skp2) complex (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Ubiquitination of phospho-p27/p21 (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
S Phase (Mus musculus)
Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
Association of Cks1 with SCF(Skp2) complex (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Ubiquitination of phospho-p27/p21 (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
Nuclear events mediated by NFE2L2 (Mus musculus)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
BTRC binds p-S344, 347 NFE2L2 (Mus musculus)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Mus musculus)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Regulation of BACH1 activity (Mus musculus)
BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
DNA Replication (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional regulation by RUNX2 (Mus musculus)
Regulation of RUNX2 expression and activity (Mus musculus)
SCF(SKP2) complex binds RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Cul1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WTX6
Gene Names
Cul1
Reference Genes
BioGPS Gene:26965 Cul1
ENSEMBL:ENSMUSG00000029686
KEGG:mmu:26965 Cul1
Monarch:26965 Cul1
NCBI Gene:26965 Cul1
UCSC:Q9WTX6 Cul1
Reference Transcript
RefSeq:XM_006506188.3 Cul1
RefSeq:XM_006506189.3 Cul1
RefSeq:NM_012042.3 Cul1
RefSeq:XM_006506190.3 Cul1
Other Identifiers
10537882
1448174_at
17458074
26965
4310657
4322545
4384516
4395363
4397665
4400116
4408214
4409966
4415027
4435294
4473544
4506306
4541793
4549578
4699993
4765131
4817283
4827226
4865939
4899606
4934977
4939861
4963379
4989193
5018559
5025562
5100455
5107068
5140209
5145975
5200993
5234906
5236058
5307773
5372266
5418750
5438950
5541274
5553124
94002_at
A_52_P149250
A_52_P664699
A_55_P2608425
A_55_P2608430
GO:0003824
GO:0005515
GO:0005886
GO:0006511
GO:0006513
GO:0006915
GO:0008283
GO:0009887
GO:0012501
GO:0016567
GO:0016740
GO:0019005
GO:0030163
GO:0030674
GO:0031146
GO:0031461
GO:0031625
GO:0043123
GO:0043161
GO:0060090
GO:0061630
GO:0070936
GO:0140096
GO:0160072
GO:1990452
ILMN_1222157
ILMN_1226323
mMC009289
Participates
as a component of
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Other forms of this molecule
Cul1 [cytosol]
Cul1 [cytosol]
Inferred From
CUL1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006506251.1
,
XP_006506252.1
,
NP_036172.1
,
XP_006506253.1
ENSEMBL
ENSMUST00000031697
,
ENSMUSP00000031697
PRO
Q9WTX6
GlyGen
Q9WTX6
MGI
1349658
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.499
2
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.499
3
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