HNF6 transactivates Onecut3 during early pancreas specification

Stable Identifier
R-MMU-187246
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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HNF6 transactivates Onecut3 during early pancreas specification

Studies in Hnf6/Onecut1 knock-out embryos showed that HNF6 is required for expression of the Onecut3 gene in the mouse endoderm, and that both protein products, HNF6/ONECUT1 and ONECUT3 co-localize in the endoderm and in embryonic pancreas (Pierreux et al. 2004). The same authors demonstrated through transfection, chromatin immunoprecipitation, and whole embryo electroporation experiments, that HNF6/ONECUT1 binds to and stimulates the expression of Onecut3.

Literature References
PubMed ID Title Journal Year
15381696 The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm

Pierreux, CE, Vanhorenbeeck, V, Jacquemin, P, Lemaigre, FP, Rousseau, GG

J Biol Chem 2004
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