HNF6 transactivates Onecut3 during early pancreas specification

Stable Identifier
R-MMU-187246
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
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PNG
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HNF6 transactivates Onecut3 during early pancreas specification
Studies in Hnf6/Onecut1 knock-out embryos showed that HNF6 is required for expression of the Onecut3 gene in the mouse endoderm, and that both protein products, HNF6/ONECUT1 and ONECUT3 co-localize in the endoderm and in embryonic pancreas (Pierreux et al. 2004). The same authors demonstrated through transfection, chromatin immunoprecipitation, and whole embryo electroporation experiments, that HNF6/ONECUT1 binds to and stimulates the expression of Onecut3.
Literature References
PubMed ID Title Journal Year
15381696 The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm

Rousseau, GG, Jacquemin, P, Lemaigre, FP, Vanhorenbeeck, V, Pierreux, CE

J Biol Chem 2004
Participants
Output
This event is regulated
Positively by
Regulator
hnf6/onecut1 [nucleoplasm] (Mus musculus)
Orthologous Events
HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification (Homo sapiens)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
Tello-Ruiz, MK  (2006-09-12)
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