HNF6 positively regulates Hnf1b expression

Stable Identifier
R-MMU-186679
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HNF6 positively regulates Hnf1b expression
Expression of Hnf1-beta is markedly reduced in early pancreatic epithelial cells of Hnf6-deficient mice, in which formation of Ngn3+ cells is defective (Maestro et al. 2003).
Literature References
PubMed ID Title Journal Year
14570708 Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

Servitja, JM, Rousseau, GG, Cabedo, J, Lemaigre, FP, Pierreux, CE, Maestro, MA, Ferrer, J, German, MS, Luco, RF, Boj, SF

Hum Mol Genet 2003
Participants
Output
This event is regulated
Positively by
Regulator
hnf6/onecut1 [nucleoplasm] (Mus musculus)
Orthologous Events
HNF6-dependent synthesis of HNF1B protein (Homo sapiens)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
Tello-Ruiz, MK  (2006-08-14)
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