HNF1a regulates Hnf4a

Stable Identifier
R-MMU-186663
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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HNF1a regulates Hnf4a

Hnf1a was shown to bind the Hnf4a promoter by chromatin immunoprecipitation (Boj et al, 2001). Genetic evidence exists that Hnf1a regulates Hnf4a in Hnf1alpha -/- mice (Boj et al, 2001, Shih et al 2001). This is supported by human genetic evidence that a mutation in the Hnf1 binding site of the Hnf4a P2 promoter causes a similar subtype of diabetes as mutations in the coding region of Hnf4a (Hansen et al, 2002).

Literature References
PubMed ID Title Journal Year
11717395 A transcription factor regulatory circuit in differentiated pancreatic cells

Boj, SF, Parrizas, M, Maestro, MA, Ferrer, J

Proc Natl Acad Sci U S A 2001
11679424 Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

Shih, DQ, Screenan, S, Munoz, KN, Philipson, L, Pontoglio, M, Yaniv, M, Polonsky, KS, Stoffel, M

Diabetes 2001
12235114 Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function

Hansen, SK, Parrizas, M, Jensen, ML, Pruhova, S, Ek, J, Boj, SF, Johansen, A, Maestro, MA, Rivera, F, Eiberg, H, Andel, M, Lebl, J, Pedersen, O, Ferrer, J, Hansen, T

J Clin Invest 2002
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