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PIK3CA:PIK3R1 [cytosol]
Stable Identifier
R-MMU-1806218
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
PI Metabolism (Mus musculus)
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)
PIK3C(1) [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)
PIK3(2) [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI3K bound to EPOR [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
GAB1 signalosome (Mus musculus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Signaling by ERBB2 (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Signaling by ERBB4 (Mus musculus)
PI3K events in ERBB4 signaling (Mus musculus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Mus musculus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Signaling by MET (Mus musculus)
MET activates PI3K/AKT signaling (Mus musculus)
MET bound PI3K generates PIP3 (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
PIK3CA:PIK3R1 [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Pik3ca [cytosol]
(Mus musculus)
Pik3r1 [cytosol]
(Mus musculus)
Participates
as a member of
PI3K alpha, gamma [cytosol] (Mus musculus)
PIK3C(1) [cytosol] (Mus musculus)
PIK3(2) [cytosol] (Mus musculus)
as an input of
Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Mus musculus)
as a component of
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Mus musculus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Mus musculus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
Inferred From
PIK3CA:PIK3R1 [cytosol]
(Homo sapiens)
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