Reactome | Rad1 [nucleoplasm]

Rad1 [nucleoplasm]

Stable Identifier

R-MMU-176382

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

RAD1, Q9QWZ1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - Activation of ATR in response to replication stress (Mus musculus)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)

DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - Homology Directed Repair (Mus musculus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
      - HDR through Single Strand Annealing (SSA) (Mus musculus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
      - Processing of DNA double-strand break ends (Mus musculus)
        
        ATR activation at DNA DSBs (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        ATR phosphorylates RPA2 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        Activation of CHEK1 at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        CHEK1 is recruited to resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Phosphorylation (Mus musculus)
        
        ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        Rad1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QWZ1

Gene Names

Rad1

Reference Genes

BioGPS Gene:19355 Rad1

ENSEMBL:ENSMUSG00000022248

ENSEMBL:ENSMUSG00000022248.15 Rad1

KEGG Gene (Mus musculus):19355 Rad1

Monarch:19355 Rad1

NCBI Gene:19355 Rad1

UCSC:Q9QWZ1 Rad1

Reference Transcript

Other Identifiers

10423068

1448414_at

17310304

19355

4422009

4562390

4598640

4746135

4879676

4914299

4930580

4947590

5206471

5294268

5304577

99005_at

A_52_P278192

A_55_P2083972

A_66_P108792

GE35983

GO:0000077

GO:0000228

GO:0003824

GO:0004518

GO:0004527

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006974

GO:0008311

GO:0008408

GO:0016787

GO:0022414

GO:0023052

GO:0030896

GO:0043226

GO:0043231

GO:0051598

GO:0071479

GO:0140013

GO:0140097

ILMN_2671447

mMC008229

Participates

as a component of

RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)

Inferred From

RAD1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001276377.1, NP_001276376.1, NP_035362.2

Ensembl

ENSMUST00000100775, ENSMUSG00000022248, ENSMUSP00000098338, ENSMUST00000022856, ENSMUSP00000022856

PRO

Q9QWZ1

MGI

1316678

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