Reactome | Rad9b [nucleoplasm]

Rad9b [nucleoplasm]

Stable Identifier

R-MMU-176325

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

RAD9B, Q6WBX7

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - Activation of ATR in response to replication stress (Mus musculus)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)

DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - Homology Directed Repair (Mus musculus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
      - HDR through Single Strand Annealing (SSA) (Mus musculus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
      - Processing of DNA double-strand break ends (Mus musculus)
        
        ATR activation at DNA DSBs (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        ATR phosphorylates RPA2 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        Activation of CHEK1 at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        CHEK1 is recruited to resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Phosphorylation (Mus musculus)
        
        ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Mus musculus)
        
        RAD9 [nucleoplasm] (Mus musculus)
        
        Rad9b [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6WBX7

Gene Names

Rad9b

Reference Genes

BioGPS Gene:231724 Rad9b

ENSEMBL:ENSMUSG00000038569

ENSEMBL:ENSMUSG00000038569.14 Rad9b

KEGG Gene (Mus musculus):231724 Rad9b

Monarch:231724 Rad9b

NCBI Gene:231724 Rad9b

UCSC:Q6WBX7 Rad9b

Reference Transcript

RefSeq:NM_144912.3 Rad9b

Other Identifiers

10533462

1425800_at

17452378

231724

4377905

4512761

4570453

4757256

4831619

4939215

5240239

5419892

5487160

5508397

5527693

5559921

5594379

A_51_P513013

GE130398

GO:0000076

GO:0000077

GO:0000228

GO:0000278

GO:0005634

GO:0005694

GO:0006281

GO:0023052

GO:0030896

GO:0031573

GO:0043226

GO:0071479

ILMN_1225080

mMC021931

Participates

as a member of

RAD9 [nucleoplasm] (Mus musculus)

Inferred From

RAD9B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_659161.2

Ensembl

ENSMUST00000049009, ENSMUSG00000038569, ENSMUSP00000036177

PRO

Q6WBX7

MGI

2385231

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