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Shelterin complex [nucleoplasm]
Stable Identifier
R-MMU-174898
Type
Complex
Species
Mus musculus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Chromosome Maintenance (Mus musculus)
Telomere Maintenance (Mus musculus)
Extension of Telomeres (Mus musculus)
Telomere C-strand (Lagging Strand) Synthesis (Mus musculus)
Disassociation of Processive Complex and Completed Telomere End (Mus musculus)
Extended And Processed Telomere End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Polymerase switching on the C-strand of the telomere (Mus musculus)
Formation of Processive Complex on the C-strand of the telomere (Mus musculus)
Processive complex loaded on telomere [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive synthesis on the C-strand of the telomere (Mus musculus)
Formation of C-strand Okazaki fragments (Mus musculus)
Processive complex loaded on telomere [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Formation of the Flap Intermediate on the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Removal of the Flap Intermediate from the C-strand (Mus musculus)
RPA binds to the Flap on the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Recruitment of DNA2 endonuclease to the C strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Removal of remaining Flap from the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomere C-strand synthesis initiation (Mus musculus)
DNA polymerase:primase binds G-strand of the telomere (Mus musculus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomere Extension By Telomerase (Mus musculus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
CDK2:CCNA phosphorylates TERF2 (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Elongation Of The Telomeric Chromosome End (Mus musculus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Elongation of Extended Telomeric Chromosome End (Mus musculus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Inhibition of DNA recombination at telomere (Mus musculus)
ATRX:DAXX binds to subtelomeric chromosomal regions (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Histone H3.3 deposition at telomere (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
Telomere shortening during replicative exhaustion (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Base-Excision Repair, AP Site Formation (Mus musculus)
Depurination (Mus musculus)
Cleavage of the damaged purine (Mus musculus)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Mus musculus)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Recognition and association of DNA glycosylase with site containing an affected purine (Mus musculus)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Acd [nucleoplasm]
(Mus musculus)
Pot1 [nucleoplasm]
(Mus musculus)
TERF1 homodimer [nucleoplasm]
(Mus musculus)
TERF2 homodimer [nucleoplasm]
(Mus musculus)
x 2
Terf2ip [nucleoplasm]
(Mus musculus)
Tinf2 [nucleoplasm]
(Mus musculus)
Participates
as a component of
AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Mus musculus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
as an output of
Telomere shortening during replicative exhaustion (Mus musculus)
Inferred From
Shelterin complex [nucleoplasm]
(Homo sapiens)
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