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Pot1 [nucleoplasm]
Stable Identifier
R-MMU-174890
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
POT1, Q91WC1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Chromosome Maintenance (Mus musculus)
Telomere Maintenance (Mus musculus)
Extension of Telomeres (Mus musculus)
Telomere C-strand (Lagging Strand) Synthesis (Mus musculus)
Disassociation of Processive Complex and Completed Telomere End (Mus musculus)
Extended And Processed Telomere End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Polymerase switching on the C-strand of the telomere (Mus musculus)
Formation of Processive Complex on the C-strand of the telomere (Mus musculus)
Processive complex loaded on telomere [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Mus musculus)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive synthesis on the C-strand of the telomere (Mus musculus)
Formation of C-strand Okazaki fragments (Mus musculus)
Processive complex loaded on telomere [nucleoplasm] (Mus musculus)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Formation of the Flap Intermediate on the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Removal of the Flap Intermediate from the C-strand (Mus musculus)
RPA binds to the Flap on the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Recruitment of DNA2 endonuclease to the C strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Removal of remaining Flap from the C-strand (Mus musculus)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomere C-strand synthesis initiation (Mus musculus)
DNA polymerase:primase binds G-strand of the telomere (Mus musculus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Mus musculus)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomere Extension By Telomerase (Mus musculus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
CDK2:CCNA phosphorylates TERF2 (Mus musculus)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Mus musculus)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Elongation Of The Telomeric Chromosome End (Mus musculus)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Elongation of Extended Telomeric Chromosome End (Mus musculus)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
PP6-PPP6R3 dephosphorylates TERF2 (Mus musculus)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Mus musculus)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Inhibition of DNA recombination at telomere (Mus musculus)
ATRX:DAXX binds to subtelomeric chromosomal regions (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Histone H3.3 deposition at telomere (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
Telomere shortening during replicative exhaustion (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
Base Excision Repair (Mus musculus)
Base-Excision Repair, AP Site Formation (Mus musculus)
Depurination (Mus musculus)
Cleavage of the damaged purine (Mus musculus)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Mus musculus)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Recognition and association of DNA glycosylase with site containing an affected purine (Mus musculus)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
Pot1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q91WC1 Pot1
Gene Names
Pot1, Pot1a
Chain
chain:1-640
Reference Genes
BioGPS Gene:101185 Pot1
CTD Gene:101185 Pot1
ENSEMBL:ENSMUSG00000029676.16 Pot1
KEGG Gene (Mus musculus):101185 Pot1
Monarch:101185 Pot1
NCBI Gene:101185 Pot1
UCSC:Q91WC1 Pot1
Reference Transcript
RefSeq:NM_133931.4 Pot1
Other Identifiers
101185
10543471
1448379_at
163529_at
17465246
4314437
4412709
4442227
4485800
4630003
4639417
4676189
4716570
4765991
4802194
4811934
4832821
4975633
5121167
5175983
5179664
5214339
5265083
5341115
5374086
5385314
5480264
5545486
A_51_P181152
A_55_P2115458
A_55_P2506055
A_66_P132752
GE102597
GE127654
GO:0000723
GO:0000781
GO:0000783
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0007004
GO:0010521
GO:0016233
GO:0017151
GO:0032200
GO:0032202
GO:0032206
GO:0032210
GO:0032211
GO:0032212
GO:0032508
GO:0042162
GO:0043047
GO:0043226
GO:0051276
GO:0060383
GO:0061820
GO:0061821
GO:0070187
GO:0070200
GO:0098505
GO:0098772
GO:1905773
GO:1990955
GO:2001032
ILMN_1259980
mMC004954
Participates
as a component of
AP-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Mus musculus)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Mus musculus)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Mus musculus)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Mus musculus)
Shelterin complex [nucleoplasm] (Mus musculus)
as an output of
Telomere shortening during replicative exhaustion (Mus musculus)
Other forms of this molecule
Protection of telomeres protein 1 [nucleoplasm]
Inferred From
POT1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_598692.1
Ensembl
ENSMUST00000166445
,
ENSMUST00000115330
,
ENSMUSG00000029676
,
ENSMUSP00000131928
,
ENSMUSP00000110986
PRO
Q91WC1
MGI
2141503
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96AP0 ACD
1
ACD [nucleoplasm]
(R-HSA-174889)
0.589
3
UniProt:O89023 TPP1
0.508
2
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