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SMAD4 [cytosol]
Stable Identifier
R-MMU-170862
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P97471
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Signaling by NODAL (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
WWTR1:SMAD translocates to the nucleus (Mus musculus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by Activin (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
Signaling by BMP (Mus musculus)
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
WWTR1:SMAD translocates to the nucleus (Mus musculus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
SMAD4 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P97471 Smad4
Gene Names
Smad4, Dpc4, Madh4
Chain
chain:1-551
Reference Genes
BioGPS Gene:17128 Smad4
ENSEMBL:ENSMUSG00000024515.14 Smad4
KEGG Gene (Mus musculus):17128 Smad4
Monarch:17128 Smad4
NCBI Gene:17128 Smad4
UCSC:P97471 Smad4
Reference Transcript
RefSeq:NM_008540.2 Smad4
Other Identifiers
10459705
1422485_at
1422486_a_at
1422487_at
160440_at
17128
17355366
4353907
4395889
4627720
4755664
4814473
4889622
4893342
4963865
4967060
4969979
4993511
5062215
5075953
5080370
5174729
5219125
5221946
5224601
5340457
5443671
5456001
5583757
A_52_P611867
A_55_P2112617
A_55_P2112622
A_55_P2745667
GE33977
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001222
GO:0001223
GO:0001228
GO:0001541
GO:0001649
GO:0001657
GO:0001658
GO:0001666
GO:0001701
GO:0001702
GO:0001822
GO:0001837
GO:0003012
GO:0003148
GO:0003190
GO:0003198
GO:0003220
GO:0003251
GO:0003279
GO:0003360
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005518
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006879
GO:0007010
GO:0007179
GO:0007283
GO:0007338
GO:0007369
GO:0007411
GO:0007492
GO:0007498
GO:0008092
GO:0008283
GO:0008285
GO:0008584
GO:0008585
GO:0009653
GO:0009952
GO:0010614
GO:0010628
GO:0010631
GO:0010666
GO:0010718
GO:0012501
GO:0014033
GO:0014898
GO:0017015
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030198
GO:0030308
GO:0030325
GO:0030509
GO:0030511
GO:0030513
GO:0031005
GO:0032444
GO:0032525
GO:0032909
GO:0032991
GO:0033686
GO:0035556
GO:0036302
GO:0042118
GO:0042127
GO:0042177
GO:0042733
GO:0042802
GO:0042803
GO:0043199
GO:0043226
GO:0043565
GO:0044877
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0046881
GO:0048382
GO:0048589
GO:0048663
GO:0048665
GO:0048729
GO:0048733
GO:0048856
GO:0048859
GO:0048870
GO:0050886
GO:0051797
GO:0055065
GO:0060065
GO:0060391
GO:0060395
GO:0060412
GO:0060956
GO:0061040
GO:0061629
GO:0062009
GO:0070102
GO:0070371
GO:0070373
GO:0070411
GO:0070412
GO:0071141
GO:0071144
GO:0071333
GO:0071559
GO:0071560
GO:0072133
GO:0072134
GO:0072520
GO:0090090
GO:0090575
GO:0097191
GO:0140110
GO:1901203
GO:1902895
GO:1905305
ILMN_2425011
ILMN_2706631
U79748_s_at
aa542171_at
mMC007586
mMR031218
Participates
as an input of
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Mus musculus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Mus musculus)
as a component of
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Mus musculus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Mus musculus)
as an output of
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
Other forms of this molecule
Smad4 [nucleoplasm]
phospho-RibC-SMAD4 [nucleoplasm]
Ub-SMAD4 [nucleoplasm]
Ub-SMAD4 [cytosol]
SMAD4 [nucleoplasm]
Inferred From
SMAD4 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_032566.2
Ensembl
ENSMUSP00000110589
,
ENSMUSG00000024515
,
ENSMUSP00000025393
,
ENSMUST00000025393
,
ENSMUST00000114939
PRO
P97471
MGI
894293
HMDB Protein
HMDBP14461
PDB
3QSV
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8BUN5 Smad3
10
Ub-SMAD3 [cytosol]
(R-MMU-6782830)
Smad3 [nucleoplasm]
(R-MMU-4006003)
phospho-p-S208-SMAD3 [cytosol]
(R-MMU-9731114)
SMAD3 [nucleoplasm]
(R-MMU-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-MMU-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-MMU-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-MMU-2176471)
SMAD3 [cytosol]
(R-MMU-170855)
p-S423,425-Smad3 [cytosol]
(R-MMU-9605416)
p-S423,425-Smad3 [nucleoplasm]
(R-MMU-1225907)
0.731
6
UniProt:Q60698
1
Ski [nucleoplasm]
(R-MMU-173473)
0.524
3
UniProt:Q8R1H0 HOP
0.499
2
UniProt:O95411 TIAF1
0.454
2
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