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phospho-p-S257,T261-MAP2K4 [cytosol]
Stable Identifier
R-MMU-168170
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P47809
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
Oxidative Stress Induced Senescence (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Phosphorylation of MEK4 by MEKK1 (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Mus musculus)
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
phospho-p-S257,T261-MAP2K4 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P47809 Map2k4
Gene Names
Map2k4, Jnkk1, Mek4, Mkk4, Prkmk4, Sek1, Serk1, Skk1
Chain
initiator methionine:, chain:2-397
Reference Genes
BioGPS Gene:26398 Map2k4
ENSEMBL:ENSMUSG00000033352.12 Map2k4
KEGG Gene (Mus musculus):26398 Map2k4
Monarch:26398 Map2k4
NCBI Gene:26398 Map2k4
UCSC:P47809 Map2k4
Reference Transcript
RefSeq:NM_009157.5 Map2k4
Other Identifiers
10387014
111507_at
1426233_at
1451982_at
17264189
26398
4397585
4523064
4578768
4673675
4741847
4958730
5004229
5005913
5040659
5153123
5154961
5164226
5318715
5499938
5542069
99960_at
A_51_P471440
A_55_P2018292
A_55_P2098335
A_55_P2590349
GE33147
GO:0000165
GO:0000166
GO:0001934
GO:0003012
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006260
GO:0006468
GO:0006915
GO:0007254
GO:0008545
GO:0009611
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030424
GO:0032839
GO:0034390
GO:0036211
GO:0036481
GO:0043065
GO:0043204
GO:0043226
GO:0043525
GO:0045740
GO:0046330
GO:0048856
GO:0051770
GO:0060090
GO:0061049
GO:0071260
GO:0072709
GO:0106310
GO:0140096
GO:2000672
ILMN_2773179
ILMN_2920549
U18310_s_at
mMC017623
Participates
as an output of
Phosphorylation of MEK4 by MEKK1 (Mus musculus)
as a member of
p-MAP2K4/p-MAP2K7 [cytosol] (Mus musculus)
Other forms of this molecule
p-S255,T259-Map2k4 [cytosol]
Map2k4 [cytosol]
MAP2K4 [cytosol]
Inferred From
p-S257,T261-MAP2K4 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 257 (in Homo sapiens)
Coordinate
257
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 261 (in Homo sapiens)
Coordinate
261
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_033183.1
Ensembl
ENSMUST00000046963
,
ENSMUSG00000033352
,
ENSMUSP00000041282
PRO
P47809
MGI
1346869
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53349 Map3k1
4
p-T1381,T1393-Mekk1 [cytosol]
(R-MMU-2685598)
Mekk1 [cytosol]
(R-MMU-933457)
MAP3K1 [cytosol]
(R-MMU-166866)
phospho-p-T1400,T1412-MAP3K1 [cytosol]
(R-MMU-2685607)
0.589
2
UniProt:Q9ESN9-2 MAPK8IP3
0.499
3
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