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Nfkbia [cytosol]
Stable Identifier
R-MMU-168151
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
NFKBIA, Q9Z1E3
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Downstream signaling events of B Cell Receptor (BCR) (Mus musculus)
Activation of NF-kappaB in B cells (Mus musculus)
Activated IKK phosphorylates I-kappaB (Mus musculus)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Mus musculus)
NF-KappaB p50:p50:IKBA [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappaB p50:c-Rel:IkB [cytosol] (Mus musculus)
IKB alpha,beta,epsilon [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappaB p50:p65:IKB [cytosol] (Mus musculus)
IKB alpha,beta,epsilon [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappaB p65:p65:IKB [cytosol] (Mus musculus)
IKB alpha,beta,epsilon [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
ZBP1(DAI) mediated induction of type I IFNs (Mus musculus)
RIP-mediated NFkB activation via ZBP1 (Mus musculus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF6 mediated NF-kB activation (Mus musculus)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
NFkB inhibitor:NFkB complex [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP11 deubiquitinates NFKBIA (Mus musculus)
USP11:NFKBIA [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
Nfkbia [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9Z1E3
Gene Names
Nfkbia
Reference Genes
BioGPS Gene:18035 Nfkbia
ENSEMBL:ENSMUSG00000021025
KEGG:mmu:18035 Nfkbia
Monarch:18035 Nfkbia
NCBI Gene:18035 Nfkbia
UCSC:Q9Z1E3 Nfkbia
Reference Transcript
RefSeq:NM_010907.2 Nfkbia
Other Identifiers
101554_at
10400405
104149_at
1420088_at
1438157_s_at
1448306_at
1449731_s_at
167965_f_at
17281219
18035
4451306
4456762
4463827
4496358
4562503
4656923
4875402
5133338
5192343
5236867
5288857
A_51_P295192
GE35801
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0007219
GO:0007249
GO:0008139
GO:0010468
GO:0010745
GO:0010875
GO:0010888
GO:0019899
GO:0031072
GO:0031625
GO:0031663
GO:0032495
GO:0032496
GO:0032991
GO:0033209
GO:0034142
GO:0035994
GO:0038061
GO:0042127
GO:0042802
GO:0043124
GO:0043226
GO:0043330
GO:0044877
GO:0045638
GO:0045746
GO:0045893
GO:0045944
GO:0050729
GO:0050853
GO:0051059
GO:0051247
GO:0060261
GO:0070427
GO:0070431
GO:0070498
GO:0071345
GO:0071356
GO:0071407
GO:0098772
GO:0140311
GO:0140313
GO:0140416
ILMN_1218605
Msa.1690.0_at
Msa.1690.0_g_at
mMC012597
Participates
as a component of
USP11:NFKBIA [cytosol] (Mus musculus)
NF-KappaB p50:p50:IKBA [cytosol] (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
as a member of
IKB alpha,beta,epsilon [cytosol] (Mus musculus)
NFkB inhibitor [cytosol] (Mus musculus)
as an input of
IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)
Other forms of this molecule
Nfkbia [cytosol]
Nfkbia [nucleoplasm]
Nfkbia [nucleoplasm]
phospho-Nfkbia [cytosol]
phospho-Nfkbia [cytosol]
Inferred From
NFKBIA [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035037.2
ENSEMBL
ENSMUST00000021413
,
ENSMUSP00000021413
PRO
Q9Z1E3
MGI
104741
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04207
7
Rela [nucleoplasm]
(R-MMU-177676)
Rela [cytosol]
(R-MMU-168172)
phospho-Rela [nucleoplasm]
(R-MMU-5624468)
phospho-Rela [nucleoplasm]
(R-MMU-5660642)
Rela [nucleoplasm]
(R-MMU-4755466)
phospho-Rela [nucleoplasm]
(R-MMU-9861499)
Rela [nucleoplasm]
(R-MMU-8865233)
0.912
9
UniProt:Q04863
2
Relb [nucleoplasm]
(R-MMU-5607656)
Relb [cytosol]
(R-MMU-5607652)
0.499
4
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