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phospho-p-Y-ERBB2 [plasma membrane]
Stable Identifier
R-MMU-1678589
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
P70424
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
ERBB2 Activates PTK6 Signaling (Mus musculus)
Activated ERBB2 binds PTK6 (BRK) (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 promotes PTK6 autophosphorylation (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
Downregulation of ERBB2:ERBB3 signaling (Mus musculus)
RNF41 binds neuregulin-activated ERBB3 (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
RNF41 ubiquitinates activated ERBB3 (Mus musculus)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MATK [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Mus musculus)
Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 Activates PTK6 Signaling (Mus musculus)
Activated ERBB2 binds PTK6 (BRK) (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 promotes PTK6 autophosphorylation (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
ERBB2 Regulates Cell Motility (Mus musculus)
MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
GRB7 events in ERBB2 signaling (Mus musculus)
GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
SHC1 events in ERBB2 signaling (Mus musculus)
SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-ERBB2 heterodimers [plasma membrane] (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
p-6Y-ERBB2 heterodimers [plasma membrane] (Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
phospho-p-Y-ERBB2 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P70424
Reference Genes
BioGPS Gene:13866
ENSEMBL:ENSMUSG00000062312
ENSEMBL:ENSMUSG00000062312.6
KEGG Gene (Mus musculus):13866
Monarch:13866
NCBI Gene:13866
UCSC:P70424
Reference Transcript
RefSeq:NM_001003817.1
Other Identifiers
10380896
135374_at
13866
1424919_at
17255999
4348730
4350659
4373788
4416299
4506355
4533316
4540813
4579629
4588307
4599423
4689724
4722230
4745688
4839127
4953650
4985595
5055196
5065939
5116387
5132392
5155525
5196772
5222775
5229068
5294120
5332609
5383046
5460675
5519783
5546820
5558876
5566205
5582844
5608034
A_51_P216179
A_52_P49250
A_55_P2809338
GE1479747
GO:0000166
GO:0001042
GO:0001934
GO:0002116
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005102
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0005902
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008045
GO:0008284
GO:0009925
GO:0010001
GO:0010008
GO:0010628
GO:0012501
GO:0014044
GO:0015026
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0019838
GO:0022008
GO:0022414
GO:0023052
GO:0030154
GO:0030182
GO:0030307
GO:0030971
GO:0031410
GO:0031594
GO:0031625
GO:0032587
GO:0032886
GO:0033080
GO:0033088
GO:0034330
GO:0035025
GO:0035556
GO:0036211
GO:0038127
GO:0038133
GO:0038134
GO:0038135
GO:0038143
GO:0042060
GO:0042127
GO:0042552
GO:0042734
GO:0042802
GO:0042995
GO:0043066
GO:0043125
GO:0043209
GO:0043219
GO:0043226
GO:0043235
GO:0043410
GO:0043491
GO:0044849
GO:0044877
GO:0045211
GO:0045727
GO:0045785
GO:0045943
GO:0046579
GO:0046982
GO:0048471
GO:0048485
GO:0048678
GO:0048709
GO:0048856
GO:0050679
GO:0051879
GO:0051897
GO:0060089
GO:0070372
GO:0071363
GO:0071364
GO:0071526
GO:0090314
GO:0098590
GO:0099645
GO:0140096
ILMN_2739424
mMC023403
Participates
as a component of
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
phospho-p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
phospho-p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
phospho-p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
ERBB2 [plasma membrane]
phospho-p-Y877-ERBB2 [plasma membrane]
phospho-p-Y,Y877-ERBB2 [plasma membrane]
phospho-p-6Y-ERBB2 [plasma membrane]
phospho-p-7Y-ERBB2 [plasma membrane]
phospho-p-6Y,Y1112-ERBB2 [plasma membrane]
phospho-p-7Y,Y1112-ERBB2 [plasma membrane]
Inferred From
p-Y-ERBB2 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001003817.1
IntEnz
2.7.10.1
Ensembl
ENSMUST00000058295
,
ENSMUSP00000053897
,
ENSMUSG00000062312
PRO
P70424
MGI
95410
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q80TH2
1
Erbin [plasma membrane]
(R-MMU-1358718)
0.668
8
UniProt:P42227 Stat3
13
phospho-Stat3 [nucleoplasm]
(R-MMU-1112554)
phospho-Stat3 [cytosol]
(R-MMU-914048)
Stat3 [cytosol]
(R-MMU-539044)
Stat3 [cytosol]
(R-MMU-914084)
p-Y705-Stat3 [cytosol]
(R-MMU-914034)
p(Y705)-Stat3 [nucleoplasm]
(R-MMU-2730582)
phospho-Stat3 [cytosol]
(R-MMU-8983130)
phospho-Stat3 [nucleoplasm]
(R-MMU-9027589)
phospho-Stat3 [cytosol]
(R-MMU-539048)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701429)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701435)
phospho-Stat3 [cytosol]
(R-MMU-8982823)
phospho-Stat3 [nucleoplasm]
(R-MMU-8983188)
0.537
4
UniProt:P18762 Adrb2
6
phospho-Adrb2 [clathrin-coated endocytic vesicle membrane]
(R-MMU-8869143)
Adrb2 [endosome membrane]
(R-MMU-6783036)
Adrb2 [endosome membrane]
(R-MMU-6783066)
phospho-Adrb2 [plasma membrane]
(R-MMU-8852158)
Beta-2 adrenergic receptor [plasma membrane]
(R-MMU-421951)
Adrb2 [plasma membrane]
(R-MMU-390647)
0.524
3
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