Reactome | PTPN11 [cytosol]

PTPN11 [cytosol]

Stable Identifier

R-MMU-162563

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P35235

Locations in the PathwayBrowser for interactor UniProt:O35718 Socs3

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External Reference Information

External Reference

UniProt:P35235 Ptpn11

Gene Names

Ptpn11

Chain

initiator methionine:, chain:2-593

Reference Genes

BioGPS Gene:19247 Ptpn11

ENSEMBL:ENSMUSG00000043733.15 Ptpn11

KEGG Gene (Mus musculus):19247 Ptpn11

Monarch:19247 Ptpn11

NCBI Gene:19247 Ptpn11

UCSC:P35235 Ptpn11

Reference Transcript

Other Identifiers

102874_at

10533285

114636_at

1421196_at

1427699_a_at

1451225_at

17452161

19247

4322855

4329015

4478855

4507916

4518283

4524274

4566118

4618693

4664661

4849125

4891955

5199118

5200785

5319892

5406406

5431131

5469518

5614591

A_51_P173622

A_52_P211393

A_52_P641185

A_66_P101820

GE35963

GO:0000077

GO:0000278

GO:0001784

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005158

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006470

GO:0006629

GO:0006641

GO:0006886

GO:0006913

GO:0007155

GO:0007165

GO:0007173

GO:0007229

GO:0007409

GO:0007420

GO:0007507

GO:0008543

GO:0009755

GO:0009967

GO:0016311

GO:0016787

GO:0016791

GO:0019901

GO:0019904

GO:0021697

GO:0022414

GO:0023052

GO:0030154

GO:0030159

GO:0030220

GO:0030971

GO:0031748

GO:0032331

GO:0032480

GO:0032528

GO:0032728

GO:0032755

GO:0032760

GO:0032991

GO:0033628

GO:0033629

GO:0034330

GO:0035264

GO:0035265

GO:0035335

GO:0035855

GO:0036211

GO:0036302

GO:0038127

GO:0042445

GO:0042593

GO:0043226

GO:0043254

GO:0043274

GO:0043408

GO:0043560

GO:0044853

GO:0045296

GO:0045778

GO:0045931

GO:0046326

GO:0046628

GO:0046676

GO:0046825

GO:0046887

GO:0046888

GO:0048008

GO:0048011

GO:0048013

GO:0048609

GO:0048806

GO:0048839

GO:0048856

GO:0048870

GO:0048873

GO:0050731

GO:0050839

GO:0050886

GO:0051428

GO:0051463

GO:0051894

GO:0055085

GO:0060020

GO:0060090

GO:0060125

GO:0060325

GO:0061582

GO:0065003

GO:0070374

GO:0071260

GO:0071310

GO:0071364

GO:0140096

GO:1990782

ILMN_1245874

ILMN_2681329

ILMN_2723559

ILMN_2743723

ILMN_3001598

d84372_s_at

mMC000988

mMC014708

mMC023487

mMR027502

Participates

as an input of

as a component of

as a member of

PTPN6,PTPN11 [cytosol] (Mus musculus)

This entity regulates

Negatively

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)

Other forms of this molecule

p-Y546,Y584-Shp2 [cytosol]

PTPN11 [nucleoplasm]

Ptpn11 [cytosol]

phospho-p-Y542,Y580-PTPN11 [cytosol]

Inferred From

PTPN11 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_035332.1, NP_001103462.1

Ensembl

ENSMUST00000054547, ENSMUSG00000043733, ENSMUSP00000098333, ENSMUST00000100770, ENSMUSP00000058757

PRO

P35235

MGI

99511

PDB

1AYD, 1AYB, 1AYC, 1AYA

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.809	7
UniProt:Q60631 Grb2	3	Grb2 [cytosol] (R-MMU-74686) Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-443287)	0.59	3
UniProt:P97484	15	Lilrb3 [plasma membrane] (R-MMU-197721-6) Lilrb3 [plasma membrane] (R-MMU-3006558-6) Lilrb3 [plasma membrane] (R-MMU-6786744-6) Lilrb3 [plasma membrane] (R-MMU-6786745-6) Lilrb3 [plasma membrane] (R-MMU-6786742-6) Lilrb3 [plasma membrane] (R-MMU-197730-6) Lilrb3 [specific granule membrane] (R-MMU-6801372-6) Lilrb3 [ficolin-1-rich granule membrane] (R-MMU-6801373-6) Lilrb3 [ficolin-1-rich granule membrane] (R-MMU-6801406-6) Lilrb3 [plasma membrane] (R-MMU-197725-6) Lilrb3 [plasma membrane] (R-MMU-6786743-6) Lilrb3 [tertiary granule membrane] (R-MMU-6801367-6) Lilrb3 [tertiary granule membrane] (R-MMU-6801392-6) Lilrb3 [plasma membrane] (R-MMU-197727-6) Lilrb3 [secretory granule membrane] (R-MMU-6803281-6)	0.589	2
UniProt:P30999 Ctnnd1	2	Ctnnd1 [plasma membrane] (R-MMU-9761465) Ctnnd1 [plasma membrane] (R-MMU-418996)	0.544	3
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417_D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.524	2
UniProt:P28776	1	IDO1 [cytosol] (R-MMU-198574)	0.499	5
UniProt:Q8K4V6 Q8K4V6			0.499	3
UniProt:P15209 Ntrk2	4	phospho-p-5Y-NTRK2 [plasma membrane] (R-MMU-9026475) Ntrk2 [plasma membrane] (R-MMU-9025038) p-5Y-Ntrk2 [plasma membrane] (R-MMU-9030410) p-5Y,S478-Ntrk2 [plasma membrane] (R-MMU-9033310)	0.499	2
UniProt:Q6Q899 Rigi	4	PolyUb-DDX58 [cytosol] (R-MMU-6782770) Rig-I [cytosol] (R-MMU-936468) K63polyUb-DDX58 [cytosol] (R-MMU-918191) DDX58 [cytosol] (R-MMU-168917)	0.462	4
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2
UniProt:O35718 Socs3	1	Socs3 [cytosol] (R-MMU-1169197)	0.462	2
UniProt:Q80ZE3	3	SIGLEC11 [plasma membrane] (R-MMU-197709) SIGLEC10 [plasma membrane] (R-MMU-197707) SIGLEC16 [plasma membrane] (R-MMU-2326826)	0.462	4

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