Phosphorylation of PDE3B by AKT-1

Stable Identifier
R-MMU-162352
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of PDE3B by AKT-1
At the beginning of this reaction, 2 molecules of 'ATP', and 1 molecule of 'PDE3B' are present. At the end of this reaction, 1 molecule of 'Phosphorylated PDE3B', and 2 molecules of 'ADP' are present.

This reaction is mediated by the 'kinase activity' of 'Phosphorylated AKT-1'.
Literature References
PubMed ID Title Journal Year
10779773 Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells

Rahn Landstrom, T, Quon, MJ, Manganiello, VC, Cong, LN, Stenson Holst, L, Ahmad, F, Degerman, E, Pierce, JH, Wang, LM

J. Immunol. 2000
10454575 Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

Kitamura, Y, Ogawa, W, Kuroda, S, Kasuga, M, Matsuzaki, H, Ando, M, Kitamura, T, Kotani, K, Kikkawa, U, Konishi, H, Hino, Y

Mol Cell Biol 1999
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-Akt1 [cytosol]

Physical Entity
p-T308,S473-Akt1 [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)
Created
de Bono, B  (2005-03-24)
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