Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Sp1 [nucleoplasm]
Stable Identifier
R-MMU-1592223
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
SP1, O89090
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Mus musculus)
Cell junction organization (Mus musculus)
Cell-cell junction organization (Mus musculus)
Adherens junctions interactions (Mus musculus)
Regulation of Homotypic Cell-Cell Adhesion (Mus musculus)
Regulation of Expression and Function of Type II Classical Cadherins (Mus musculus)
Regulation of CDH11 Expression and Function (Mus musculus)
Regulation of CDH11 gene transcription (Mus musculus)
ZEB2 binds SP1 (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
ZEB2:SP1 [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Mus musculus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RNA polymerase II transcribes snRNA genes (Mus musculus)
CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
Integrator complex processes the 3' end of snRNA (Mus musculus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Estrogen-dependent gene expression (Mus musculus)
HATs and coactivators are recruited to the CTSD gene (Mus musculus)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Mus musculus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Mus musculus)
Sp1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:O89090
Gene Names
Sp1
Reference Genes
BioGPS Gene:20683 Sp1
ENSEMBL:ENSMUSG00000001280
ENSEMBL:ENSMUSG00000001280.14 Sp1
KEGG Gene (Mus musculus):20683 Sp1
Monarch:20683 Sp1
NCBI Gene:20683 Sp1
UCSC:O89090 Sp1
Reference Transcript
RefSeq:NM_013672.2 Sp1
Other Identifiers
100032_at
10427214
1418180_at
1448994_at
17315409
20683
4343480
4547519
4623057
4688833
4732744
4742063
4802058
4807068
4822320
4879495
5161814
5187576
5388675
A_55_P2744864
GE36779
GO:0000785
GO:0000791
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001221
GO:0001228
GO:0001503
GO:0001701
GO:0001829
GO:0001889
GO:0001892
GO:0002318
GO:0002376
GO:0003677
GO:0003690
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006790
GO:0010628
GO:0016071
GO:0017053
GO:0022414
GO:0030154
GO:0030219
GO:0030324
GO:0032869
GO:0032993
GO:0033194
GO:0035035
GO:0042789
GO:0042802
GO:0042803
GO:0042826
GO:0043226
GO:0043353
GO:0043425
GO:0043536
GO:0043565
GO:0043923
GO:0045766
GO:0045893
GO:0045944
GO:0046872
GO:0048511
GO:0048596
GO:0048706
GO:0048856
GO:0048870
GO:0060090
GO:0060136
GO:0060216
GO:0061629
GO:0140110
GO:1902004
GO:1904828
GO:1905564
GO:1990837
ILMN_1249468
ILMN_2616755
Msa.2694.0_at
mMC022808
Participates
as an input of
HATs and coactivators are recruited to the CTSD gene (Mus musculus)
ZEB2 binds SP1 (Mus musculus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Mus musculus)
as a component of
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Mus musculus)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
ZEB2:SP1 [nucleoplasm] (Mus musculus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Mus musculus)
Inferred From
SP1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_038700.2
Ensembl
ENSMUSG00000001280
,
ENSMUSP00000130747
,
ENSMUST00000163709
PRO
O89090
MGI
98372
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q80Z64 Nanog
1
Nanog [nucleoplasm]
(R-MMU-9833222)
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text