Socs1 as a regulator of kit signaling

Stable Identifier
R-MMU-1524177
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Socs1 as a regulator of kit signaling

SOCS1 has been identified as a KIT binding partner from the yeast two-hybrid system (Sepulveda et al, 1999). SOCS1 expression is induced upon KIT activation. It associates with KIT via its SH2 domain. SOCS1 does not inhibit KIT kinase activity directly, instead it binds to GRB2 and VAV1, and selectively inhibits SCF-induced proliferation, while not effecting survival signal (Sepulveda et al, 1999). It has been proposed that SOCS1 may interrupt signal transduction pathways downstream of JAK2 (Sepulveda et al, 1999).

Literature References
PubMed ID Title Journal Year
10022833 Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

De Sepulveda, P, Okkenhaug, K, Rose, JL, Hawley, RG, Dubreuil, P, Rottapel, R

EMBO J 1999
Participants
Orthologous Events
Authored
Reviewed
Created
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