Reactome | Ighg1 [extracellular region]

Ighg1 [extracellular region]

Stable Identifier

R-MMU-1478808

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

IGHG2, P01869

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - Complement cascade (Mus musculus)
    - Initial triggering of complement (Mus musculus)
      - Conversion of C2 into C2a and C2b (Mus musculus)
        
        C4 activators [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Conversion of C4 into C4a and C4b (Mus musculus)
        
        C4 activators [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Creation of C4 and C2 activators (Mus musculus)
        
        Classical antibody-mediated complement activation (Mus musculus)
        
        Activation of C1r (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        Activation of C1s (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
    - Regulation of Complement cascade (Mus musculus)
      - Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - C1-Inh binds and inactivates C1r, C1s (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
    - FCGR activation (Mus musculus)
      - Cross-linking of FCGRIA with IgG-coated Ag (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        IgG-Ag:FCGRIIA [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        IgG-Ag:FCGRIIIA:CD3G/CD3Z dimers [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Recruitment of SYK to phosphorylated ITAMs (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)
        
        clustered IgG-Ag:FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
    - Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Activation of RAC1 by VAV (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Phosphorylation of VAV (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Mus musculus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Recruitment of VAV1 to p-6Y-SYK (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Role of myosins in phagosome formation (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
    - Role of phospholipids in phagocytosis (Mus musculus)
      - PI3K binds to p-6Y-SYK (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Phosphorylation and activation of PLCG (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Recruitment of PLCgamma to membrane (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
      - Release of PLCG from FCGR (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Mus musculus)
        
        Antigen:IgG [plasma membrane] (Mus musculus)
        
        IgG [extracellular region] (Mus musculus)
        
        IgG Heavy Chain [extracellular region] (Mus musculus)
        
        IgG C region [extracellular region] (Mus musculus)
        
        Ighg1 [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P01869

Gene Names

Ighg1

Reference Genes

ENSEMBL:ENSMUSG00000076614

Participates

as a member of

IgG C region [extracellular region] (Mus musculus)

Other forms of this molecule

Ighg1 [extracellular region]

Inferred From

IGHG2 [extracellular region] (Homo sapiens)

Cross References

MGI

96446

PDB

25C8, 1F11, 1KCU, 15C8, 1KEN, 1A3L, 1KCR, 1QFU, 2AJZ, 1ACY, 1IGY, 1JRH, 1CIC, 1C12, 2AK1, 2AJX, 2AJY, 1ORS, 1A0Q, 2AJV, 1S5I, 1CK0, 2AJU, 1F58, 1KC5, 1AE6, 1CL7, 2AJS

Cite Us!