RalA Hydrolyzes GTP

Stable Identifier
R-MMU-1458501
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
RalA Hydrolyzes GTP

Rala binds guanine nucleotides and hydrolyzes bound GTP to yield GDP and phosphate (Chen et al. 2007, Chen et al. 2011). The GTPase activity of Rala is regulated by interaction with GTPase-activating proteins(GAPs) (Chen et al. 2011). Rgc1 and Rgc2 are GAPs that activate Rala. Insulin signaling activates Akt, which phosphorylates Rgc2, inactivating the GAP activity of Rgc1:Rgc2 and allowing Rala:GTP to accumulate.

Literature References
PubMed ID Title Journal Year
17765682 Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c

Chen, XW, Leto, D, Chiang, SH, Wang, Q, Saltiel, AR

Dev Cell 2007
21148297 A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Chen, XW, Leto, D, Xiong, T, Yu, G, Cheng, A, Decker, S, Saltiel, AR

Mol Biol Cell 2011
Participants
Catalyst Activity
Catalyst Activity
Title
GTPase activity of GGC-Rala:GTP [cytoplasmic vesicle membrane]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Authored
Reviewed
Created