Ampk-alpha2 Phosphorylates Tbc1d1

Stable Identifier
R-MMU-1454711
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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Ampk-alpha2 Phosphorylates Tbc1d1

Ampk-alpha2 phosphorylates Tbc1d1 on serine-231 and probably other residues (Taylor et al. 2008, Peck et al. 2009, Pehmoller et al. 2009, Vichaiwong et al. 2010). Ampk-alpha2 is activated in response to muscle contraction and insulin signaling.

Literature References
PubMed ID Title Journal Year
20701589 Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

Vichaiwong, K, Purohit, S, An, D, Toyoda, T, Jessen, N, Hirshman, MF, Goodyear, LJ

Biochem J 2010
18276596 Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle

Taylor, EB, An, D, Kramer, HF, Yu, H, Fujii, NL, Roeckl, KS, Bowles, N, Hirshman, MF, Xie, J, Feener, EP, Goodyear, LJ

J Biol Chem 2008
19531644 Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

Pehmøller, C, Treebak, JT, Birk, JB, Chen, S, Mackintosh, C, Hardie, DG, Richter, EA, Wojtaszewski, JF

Am J Physiol Endocrinol Metab 2009
19740738 Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation

Peck, GR, Chavez, JA, Roach, WG, Budnik, BA, Lane, WS, Karlsson, HK, Zierath, JR, Lienhard, GE

J Biol Chem 2009
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Ampk-alpha2:Ampk-beta:Ampk-gamma:AMP [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created