Rab8a/10/13/14 Hydrolyze GTP

Stable Identifier
R-MMU-1449633
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Rab8a/10/13/14 Hydrolyze GTP

As inferred from human RAB proteins, mouse Rab proteins have weak GTPase activity which is enhanced by interaction with Rab-GTPase activating proteins (GAPs). As160 (Tbc1d4) and Tbc1d1 are GAPs that activate the GTPase activity of Rab8A/10/13. Insulin signaling activates Akt, which phosphorylates and inactivates As160 and Tbc1d1 and allows GTP-bound (active) Rab proteins to accumulate (Pan et al.2007, Li et al. 2017).

Literature References
PubMed ID Title Journal Year
28079283 Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts

Li, H, Ou, L, Fan, J, Xiao, M, Kuang, C, Liu, X, Sun, Y, Xu, Y

FEBS Lett. 2017
16855591 TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism

Pan, X, Eathiraj, S, Munson, M, Lambright, DG

Nature 2006
Participants
Catalyst Activity
Catalyst Activity
Title
GTPase activity of GGC-Rab8a,10,13,14:GTP [cytoplasmic vesicle membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created