14-3-3 Binds Phosphorylated Tbc1d4 (AS160)

Stable Identifier
R-MMU-1445145
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
14-3-3 Binds Phosphorylated Tbc1d4 (AS160)

As160 (Tbc1d4) phosphorylated on serines 324, 348, 577, 595, and 758 and threonine 649 binds 14-3-3 proteins (Ramm et al. 2006, Ngo et al. 2009). Phosphorylation of As160 does not interfere with its interaction with Irap (Lnpep) (Peck et al. 2006).

Literature References
PubMed ID Title Journal Year
16880201 A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160

Ramm, G, Larance, M, Guilhaus, M, James, DE

J Biol Chem 2006
19013499 Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

Ngo, S, Barry, JB, Nisbet, JC, Prins, JB, Whitehead, JP

Mol Cell Endocrinol 2009
16762977 Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase

Peck, GR, Ye, S, Pham, V, Fernando, RN, Macaulay, SL, Chai, SY, Albiston, AL

Mol Endocrinol 2006
Participants
Orthologous Events
Authored
Reviewed
Created