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14-3-3 sigma [cytosol]
Stable Identifier
R-MMU-1445092
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
14-3-3 protein sigma, Sfn, 1433S_MOUSE, Sfn
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G2/M Checkpoints (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Mus musculus)
Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
FOXO-mediated transcription (Mus musculus)
Regulation of localization of FOXO transcription factors (Mus musculus)
14-3-3 proteins bind AKT-phosphorylated FOXO3 (Mus musculus)
YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol] (Mus musculus)
YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
DDIT4 binds 14-3-3 dimer (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
DDIT4:14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
DDIT4:14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
TP53 Regulates Transcription of Cell Cycle Genes (Mus musculus)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Mus musculus)
SFN dimer binds BAX (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
SFN Dimer:BAX [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
SFN dimer binds CDK1 and CCNB1 (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
SFN Dimer:CCNB1:CDK1 [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
SFN dimerizes (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Intrinsic Pathway for Apoptosis (Mus musculus)
Activation of BH3-only proteins (Mus musculus)
Activation of BAD and translocation to mitochondria (Mus musculus)
Activation of BAD by calcineurin (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
Sequestration of BAD protein by 14-3-3 (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases activate PKNs (Mus musculus)
Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Mus musculus)
14-3-3 dimer [cytosol] (Mus musculus)
14-3-3 sigma dimer [cytosol] (Mus musculus)
14-3-3 sigma [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:O70456 Sfn
Gene Names
Sfn, Mkrn3
Chain
chain:1-248
Reference Genes
BioGPS Gene:55948 Sfn
KEGG:mmu:55948 Sfn
Monarch:55948 Sfn
NCBI Gene:55948 Sfn
UCSC:O70456 Sfn
Reference Transcript
RefSeq:NM_018754.2 Sfn
Other Identifiers
10517067
10572635
1448612_at
17431049
4638840
4706719
4781633
4840874
5371365
55948
96704_at
A_52_P334188
A_52_P334191
GO:0000122
GO:0001836
GO:0003334
GO:0005515
GO:0005576
GO:0005634
GO:0005737
GO:0005829
GO:0006355
GO:0006611
GO:0006886
GO:0006913
GO:0007005
GO:0007165
GO:0008104
GO:0008630
GO:0010482
GO:0010737
GO:0010839
GO:0019901
GO:0022407
GO:0030154
GO:0030216
GO:0030307
GO:0031424
GO:0032880
GO:0042802
GO:0043226
GO:0043588
GO:0043616
GO:0045184
GO:0045606
GO:0045785
GO:0045824
GO:0046827
GO:0048856
GO:0050815
GO:0051219
GO:0051726
GO:0061436
GO:0072089
GO:0140311
GO:0140313
GO:1903077
GO:1903829
GO:2000647
ILMN_2648168
ILMN_2648169
Msa.5777.0_s_at
aa670807_s_at
mMC022352
Participates
as an input of
SFN dimerizes (Mus musculus)
as a component of
14-3-3 sigma dimer [cytosol] (Mus musculus)
Inferred From
SFN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_061224.2
ENSEMBL
ENSMUST00000057311
,
ENSMUSP00000050374
PRO
O70456
MGI
1891831
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61510
2
Trim25 [nucleoplasm]
(R-MMU-5653667)
Trim25 [cytosol]
(R-MMU-918186)
0.526
3
UniProt:Q9QWL7
1
Krt17 [cytosol]
(R-MMU-201583)
0.463
3
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