Mitoferrin Transports Iron Across the Mitochondrial Inner Membrane

Stable Identifier
R-MMU-1362412
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Mitoferrin Transports Iron Across the Mitochondrial Inner Membrane

Mitoferrin-1 (Slc25a37) and Mitoferrin-2 (Slc25a28) transport ferrous iron across the inner mitochondrial membrane (Troadec et al. 2011, Shaw et al. 2006, Paradkar et al. 2009). A defect in Mitoferrin-1 causes a reduction in iron-sulfur clusters and heme (Shaw et al. 2006, Paradkar et al. 2009).

Literature References
PubMed ID Title Journal Year
21310927 Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria

Troadec, MB, Warner, D, Wallace, J, Thomas, K, Spangrude, GJ, Phillips, J, Khalimonchuk, O, Paw, BH, Ward, DM, Kaplan, J

Blood 2011
16511496 Mitoferrin is essential for erythroid iron assimilation

Shaw, GC, Cope, JJ, Li, L, Corson, K, Hersey, C, Ackermann, GE, Gwynn, B, Lambert, AJ, Wingert, RA, Traver, D, Trede, NS, Barut, BA, Zhou, Y, Minet, E, Donovan, A, Brownlie, A, Balzan, R, Weiss, MJ, Peters, LL, Kaplan, J, Zon, LI, Paw, BH

Nature 2006
19075006 Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2

Paradkar, PN, Zumbrennen, KB, Paw, BH, Ward, DM, Kaplan, J

Mol Cell Biol 2009
Participants
Catalyst Activity
Catalyst Activity
Title
ferrous iron transmembrane transporter activity of Mitoferrin [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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