Reactome | Mitoferrin Transports Iron Across the Mitochondrial Inner Membrane

Mitoferrin Transports Iron Across the Mitochondrial Inner Membrane

Stable Identifier

R-MMU-1362412

Type

Reaction [transition]

Species

Mus musculus

Compartment

mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix

ReviewStatus

5/5

General

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Mitoferrin Transports Iron Across the Mitochondrial Inner Membrane

Mitoferrin-1 (Slc25a37) and Mitoferrin-2 (Slc25a28) transport ferrous iron across the inner mitochondrial membrane (Troadec et al. 2011, Shaw et al. 2006, Paradkar et al. 2009). A defect in Mitoferrin-1 causes a reduction in iron-sulfur clusters and heme (Shaw et al. 2006, Paradkar et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
16511496	Mitoferrin is essential for erythroid iron assimilation Shaw, GC, Cope, JJ, Li, L, Corson, K, Hersey, C, Ackermann, GE, Gwynn, B, Lambert, AJ, Wingert, RA, Traver, D, Trede, NS, Barut, BA, Zhou, Y, Minet, E, Donovan, A, Brownlie, A, Balzan, R, Weiss, MJ, Peters, LL, Kaplan, J, Zon, LI, Paw, BH	Nature	2006
21310927	Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria Troadec, MB, Warner, D, Wallace, J, Thomas, K, Spangrude, GJ, Phillips, J, Khalimonchuk, O, Paw, BH, Ward, DM, Kaplan, J	Blood	2011
19075006	Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2 Paradkar, PN, Zumbrennen, KB, Paw, BH, Ward, DM, Kaplan, J	Mol Cell Biol	2009