Txnip is released from oxidized thioredoxin

Stable Identifier
R-MMU-1250256
Type
Reaction [dissociation]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Txnip is released from oxidized thioredoxin
ROS induce the dissociation of TXNIP from thioredoxin, freeing TXNIP to subsequently bind NLRP3 and bring about activation of the NLRP3 inflammasome (Zhou et al. 2010).
Literature References
PubMed ID Title Journal Year
20023662 Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Choi, I, Thorens, B, Tardivel, A, Zhou, R, Tschopp, J

Nat Immunol 2010
Participants
Input
Output
Orthologous Events
TXNIP is released from oxidized thioredoxin (Homo sapiens)
Authored
Jupe, S  (2011-04-14)
Reviewed
Kufer, TA  (2011-04-28)
Created
Jupe, S  (2011-04-15)
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