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About
What is Reactome ?
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RBX1 [nucleoplasm]
Stable Identifier
R-MMU-1234142
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
P62878
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
S Phase (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
Nuclear events mediated by NFE2L2 (Mus musculus)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
BTRC binds p-S344, 347 NFE2L2 (Mus musculus)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Mus musculus)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Regulation of BACH1 activity (Mus musculus)
BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Nuclear VBC complex ubiquitinylates HIF-alpha (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Damage Bypass (Mus musculus)
Recognition of DNA damage by PCNA-containing replication complex (Mus musculus)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Mus musculus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Mus musculus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Mus musculus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Mus musculus)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Nucleotide Excision Repair (Mus musculus)
Global Genome Nucleotide Excision Repair (GG-NER) (Mus musculus)
DNA Damage Recognition in GG-NER (Mus musculus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
PARP1 or PARP2 binds DDB2 at GG-NER site (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
UV-DDB ubiquitinates XPC (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Mus musculus)
UV-DDB:COP9 Signalosome [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Dual Incision in GG-NER (Mus musculus)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Formation of Incision Complex in GG-NER (Mus musculus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
CHD1L is recruited to GG-NER site (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Formation of the pre-incision complex in GG-NER (Mus musculus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RNF111 ubiquitinates SUMOylated XPC (Mus musculus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Recruitment of XPA and release of CAK (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SUMOylation of XPC (Mus musculus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TFIIH binds GG-NER site to form a verification complex (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Mus musculus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
Dual incision in TC-NER (Mus musculus)
3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ERCC5 and RPA bind TC-NER site (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Formation of TC-NER Pre-Incision Complex (Mus musculus)
Assembly of the pre-incision complex in TC-NER (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Mus musculus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
DNA Replication (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional regulation by RUNX2 (Mus musculus)
Regulation of RUNX2 expression and activity (Mus musculus)
SCF(SKP2) complex binds RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Mus musculus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Hedgehog (Mus musculus)
Hedgehog 'on' state (Mus musculus)
GLI2,3 are degraded by the proteasome (Mus musculus)
SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Mus musculus)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Mus musculus)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
RBX1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P62878
Reference Genes
BioGPS Gene:56438
ENSEMBL:ENSMUSG00000022400
ENSEMBL:ENSMUSG00000022400.10
KEGG Gene (Mus musculus):56438
Monarch:56438
NCBI Gene:56438
UCSC:P62878
Reference Transcript
RefSeq:NM_019712.3
Other Identifiers
10425522
10450646
1416577_a_at
1416578_at
1448387_at
17313276
4538327
4543247
4585728
4668159
4675227
4711906
4883998
4926352
5226448
5286478
5475813
56438
95124_i_at
95125_f_at
A_51_P326413
A_52_P437230
A_52_P676076
A_55_P2038121
A_55_P2725444
GE37587
GO:0000151
GO:0000209
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005680
GO:0005737
GO:0005829
GO:0006281
GO:0006511
GO:0006513
GO:0006974
GO:0007283
GO:0008190
GO:0008270
GO:0016567
GO:0016740
GO:0019005
GO:0022414
GO:0023052
GO:0030163
GO:0030891
GO:0031146
GO:0031461
GO:0031462
GO:0031463
GO:0031464
GO:0031465
GO:0031466
GO:0031467
GO:0031625
GO:0032436
GO:0032480
GO:0034450
GO:0034644
GO:0036211
GO:0042110
GO:0043123
GO:0043161
GO:0043226
GO:0044877
GO:0045116
GO:0045732
GO:0046872
GO:0060090
GO:0061629
GO:0061630
GO:0061663
GO:0070936
GO:0071230
GO:0097602
GO:0140096
GO:0140627
GO:1902499
GO:1904263
ILMN_1230583
ILMN_2606947
mMC017451
mMC021555
mMR028815
Participates
as a component of
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Mus musculus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Mus musculus)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Mus musculus)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Mus musculus)
SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
UV-DDB [nucleoplasm] (Mus musculus)
PAR-UV-DDB [nucleoplasm] (Mus musculus)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Mus musculus)
Other forms of this molecule
RBX1 [cytosol]
Inferred From
RBX1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_062686.1
IntEnz
2.3.2.27
Ensembl
ENSMUSG00000022400
,
ENSMUSP00000023036
,
ENSMUST00000023036
PRO
P62878
MGI
1891829
PDB
4A0K
,
4A0C
,
7OPC
,
7OPD
,
4A0L
© 2024
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